Detailed information of TA system TA222023

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3541136..3541796
• Replicon: chromosome
• Accession: NZ_CP085821
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain Charizard

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: Q57K70
• Locus tag: LJF63_RS17350
• Protein ID: WP_000244756.1
• Coordinates: 3541136..3541549 (-)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: S5MU13
• Locus tag: LJF63_RS17355
• Protein ID: WP_000351186.1
• Coordinates: 3541530..3541796 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJF63_RS17330 (3537077)	3537077..3538810	-	1734	WP_000813389.1	single-stranded-DNA-specific exonuclease RecJ	-
LJF63_RS17335 (3538816)	3538816..3539529	-	714	WP_000745614.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
LJF63_RS17340 (3539553)	3539553..3540449	-	897	WP_000434302.1	site-specific tyrosine recombinase XerD	-
LJF63_RS17345 (3540562)	3540562..3541083	+	522	WP_001055885.1	flavodoxin FldB	-
LJF63_RS17350 (3541136)	3541136..3541549	-	414	WP_000244756.1	protein YgfX	Toxin
LJF63_RS17355 (3541530)	3541530..3541796	-	267	WP_000351186.1	FAD assembly factor SdhE	Antitoxin
LJF63_RS17360 (3542046)	3542046..3543026	+	981	WP_000874176.1	tRNA-modifying protein YgfZ	-
LJF63_RS17365 (3543142)	3543142..3543801	-	660	WP_000250289.1	hemolysin III family protein	-
LJF63_RS17370 (3543965)	3543965..3544276	-	312	WP_001182976.1	N(4)-acetylcytidine aminohydrolase	-
LJF63_RS17375 (3544434)	3544434..3545867	+	1434	WP_001230141.1	6-phospho-beta-glucosidase BglA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 16183.15 Da
• Isoelectric Point: 10.7537

>T222023 WP_000244756.1 NZ_CP085821:c3541549-3541136 [Salmonella enterica subsp. enterica serovar Enteritidis]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Nucleotide

• Length: 414 bp

>T222023 NZ_CP117659:284952-285479 [Escherichia albertii]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTGGTTCGTCAACATCGCAATAAAATTTTGCGAGCGTATATCCTTTGTAGCAACACTC
CAGAACGTCAGGTCCTGGGATATTACACATTATCCGGCAGTTGTTTTGAACGAGCCGCACTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTCACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGAGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCATTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCTCTGAATGAAAAAGCCCATACGTTTTATCAGTCGCTGGGCTTTATCCCGTTGGTTGGAGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATTGAACTGCTTTTTACACAGAGCGATTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10550.05 Da
• Isoelectric Point: 6.0783

>AT222023 WP_000351186.1 NZ_CP085821:c3541796-3541530 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT222023 NZ_CP117659:284679-284945 [Escherichia albertii]
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGAGCTGCGGAAGTGATTGAACAGCATCGGCGGA
TGATTCTCAATGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGTTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA

Structures

Toxin

• AlphaFold DB: A0A3Z1E9V5

Antitoxin

• AlphaFold DB: A0A5I0YWH4