Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 920850..921470 Replicon chromosome
Accession NZ_CP085821
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Charizard

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag LJF63_RS04290 Protein ID WP_001280991.1
Coordinates 920850..921068 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag LJF63_RS04295 Protein ID WP_000344807.1
Coordinates 921096..921470 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF63_RS04250 (916073) 916073..916642 + 570 WP_000779802.1 YbaY family lipoprotein -
LJF63_RS04255 (916675) 916675..917064 - 390 WP_000961287.1 MGMT family protein -
LJF63_RS04265 (917295) 917295..918845 - 1551 WP_000213140.1 EAL domain-containing protein -
LJF63_RS04270 (919070) 919070..919330 + 261 WP_000801415.1 type B 50S ribosomal protein L31 -
LJF63_RS04275 (919336) 919336..919476 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
LJF63_RS04280 (919532) 919532..920002 - 471 WP_000136183.1 YlaC family protein -
LJF63_RS04285 (920120) 920120..920671 - 552 WP_001278793.1 maltose O-acetyltransferase -
LJF63_RS04290 (920850) 920850..921068 - 219 WP_001280991.1 HHA domain-containing protein Toxin
LJF63_RS04295 (921096) 921096..921470 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
LJF63_RS04300 (921966) 921966..925115 - 3150 WP_001132508.1 efflux RND transporter permease AcrB -
LJF63_RS04305 (925138) 925138..926331 - 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T222010 WP_001280991.1 NZ_CP085821:c921068-920850 [Salmonella enterica subsp. enterica serovar Enteritidis]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T222010 NZ_CP117654:3513096-3513314 [Escherichia albertii]
ATGTCCGATAAACCTTTAACAAAAACCGATTATTTGATGCGTCTGCGTCGCTGCCAGACAATTGACACGCTGGAACGTGT
TATCGAGAAAAATAAATATGAATTATCAGATAATGAATTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTTGCAGAGC
TGACTATGAATAAGCTATATGACAAGATCCCTTCCTCAGTGTGGAAATTCATTCGGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT222010 WP_000344807.1 NZ_CP085821:c921470-921096 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT222010 NZ_CP117654:3512696-3513070 [Escherichia albertii]
ATGGATGAATACTCACCAAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGTAACCATGGCTGGGTAAATGACCCAACCTCGGCAATCAATCTACAGCTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAACAGATTGATGAATATCTG
GACGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAACCGATT
GTTCCGTTGCTTTGTTAACGCCACTAAAGCGAATCCTGCAAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References