Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 259994..260510 Replicon chromosome
Accession NZ_CP085821
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Charizard

Toxin (Protein)


Gene name relE Uniprot ID B5R9I9
Locus tag LJF63_RS01195 Protein ID WP_000220582.1
Coordinates 260226..260510 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag LJF63_RS01190 Protein ID WP_000212724.1
Coordinates 259994..260236 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF63_RS01170 (255013) 255013..256146 + 1134 WP_000459957.1 amidohydrolase/deacetylase family metallohydrolase -
LJF63_RS01175 (256130) 256130..257248 + 1119 WP_001139169.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
LJF63_RS01180 (257245) 257245..257985 + 741 WP_000779259.1 KDGP aldolase family protein -
LJF63_RS01185 (258002) 258002..259916 + 1915 Protein_229 BglG family transcription antiterminator -
LJF63_RS01190 (259994) 259994..260236 + 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LJF63_RS01195 (260226) 260226..260510 + 285 WP_000220582.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LJF63_RS01200 (260514) 260514..260978 - 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LJF63_RS01205 (261100) 261100..263238 - 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
LJF63_RS01210 (263647) 263647..265299 - 1653 WP_000155048.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10912.66 Da        Isoelectric Point: 9.6743

>T222004 WP_000220582.1 NZ_CP085821:260226-260510 [Salmonella enterica subsp. enterica serovar Enteritidis]
MTYELEFDPRALKEWHKLGDTVQAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T222004 NZ_CP117654:1050163-1050315 [Escherichia albertii]
ATGCTGACAAAATATGCCCTTGTGGCAATCATCGTACTGTGTTGTACAGTACTGGGATTCACGCTGATGGTAGGCGACTC
GCTGTGTGAGTTGAGTATCAGAGAACGTGGTATGGAGTTTAAGGCAGTTCTCGCTTACGAATCGAAGAAGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT222004 WP_000212724.1 NZ_CP085821:259994-260236 [Salmonella enterica subsp. enterica serovar Enteritidis]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT222004 NZ_CP117654:c1050118-1050071 [Escherichia albertii]
GTTCGAACGTAGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656ILJ8

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References