Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 152809..153590 Replicon chromosome
Accession NZ_CP085821
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Charizard

Toxin (Protein)


Gene name TacT2 Uniprot ID B5R980
Locus tag LJF63_RS00620 Protein ID WP_000626100.1
Coordinates 153099..153590 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag LJF63_RS00615 Protein ID WP_001110452.1
Coordinates 152809..153102 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF63_RS00580 (148856) 148856..149761 + 906 WP_001268200.1 YjiK family protein -
LJF63_RS00585 (150055) 150055..150186 - 132 Protein_112 hypothetical protein -
LJF63_RS00590 (150298) 150298..150546 - 249 Protein_113 Ig-like domain-containing protein -
LJF63_RS00595 (150545) 150545..150853 + 309 WP_072095651.1 ABC transporter ATP-binding protein -
LJF63_RS00600 (150846) 150846..151133 - 288 WP_001541332.1 transcriptional regulator RtsB -
LJF63_RS00605 (151130) 151130..152005 - 876 WP_000921676.1 AraC family transcriptional regulator -
LJF63_RS00610 (152271) 152271..152492 - 222 WP_001576552.1 hypothetical protein -
LJF63_RS00615 (152809) 152809..153102 + 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
LJF63_RS00620 (153099) 153099..153590 + 492 WP_000626100.1 GNAT family N-acetyltransferase Toxin
LJF63_RS00625 (153838) 153838..154590 - 753 WP_000842433.1 non-specific acid phosphatase -
LJF63_RS00630 (154690) 154690..154767 - 78 Protein_121 porin family protein -
LJF63_RS00635 (155147) 155147..155221 + 75 Protein_122 helix-turn-helix domain-containing protein -
LJF63_RS00645 (155492) 155492..156067 - 576 WP_001188509.1 transcriptional regulator -
LJF63_RS00650 (156104) 156104..157807 - 1704 WP_000068885.1 protein-disulfide reductase DsbD -
LJF63_RS00655 (157783) 157783..158130 - 348 WP_000887832.1 divalent cation tolerance protein CutA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17645.45 Da        Isoelectric Point: 7.7297

>T222003 WP_000626100.1 NZ_CP085821:153099-153590 [Salmonella enterica subsp. enterica serovar Enteritidis]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T222003 NZ_CP117654:893305-893709 [Escherichia albertii]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCGCAGTGGCTCTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGCTATTTTACTCATGCCCTGGCCGCTAAGTTATACCCCGTTATGGATGGTGTTGCTTTCGCTGGTGGTGTTTGATTGCG
TCCGCAGTCAGCGGCGCATTAATGCTCGTCAGGGGGAGATTCGCCTGTTGATGGATGGGCGTTTACGCTGGCAGGGGCAG
GAGTGGAGCATCGTCAGAGCGCCGTGGATGATTAAAACTGGCATGATGTTGCGTTTACTCTCTGATAGCGGCAAACGTCA
GCACCTGTGGCTGGCAGCCGACAGTATGGATGAAGCTGAATGGCGGGATTTGCGGCGAATTTTGTTACAACAAGAGATAC
AGTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT222003 WP_001110452.1 NZ_CP085821:152809-153102 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT222003 NZ_CP117654:893058-893324 [Escherichia albertii]
ATGGACATTAACAATAAAGCCCGCATTCACTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGATAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGACTGCTGGAATGTGACGATCCCGATT
TATTCAACTGGTTGATGAATCACGGTAAACCGGCCGACGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IQ80

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References