221994

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 4112836..4113358 Replicon chromosome
Accession NZ_CP085820
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain Wartortle

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag LJF64_RS19760 Protein ID WP_000221343.1
Coordinates 4112836..4113120 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag LJF64_RS19765 Protein ID WP_000885424.1
Coordinates 4113110..4113358 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF64_RS19740 (4108911) 4108911..4110419 - 1509 WP_000199411.1 FAD-dependent oxidoreductase -
LJF64_RS19745 (4110464) 4110464..4110952 + 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
LJF64_RS19750 (4111145) 4111145..4112224 + 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
LJF64_RS19755 (4112276) 4112276..4112665 - 390 WP_000194089.1 RidA family protein -
LJF64_RS19760 (4112836) 4112836..4113120 - 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LJF64_RS19765 (4113110) 4113110..4113358 - 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LJF64_RS19770 (4113510) 4113510..4113725 + 216 WP_000206207.1 hypothetical protein -
LJF64_RS19775 (4113715) 4113715..4114047 + 333 WP_000253154.1 DUF1493 family protein -
LJF64_RS19780 (4114190) 4114190..4115098 + 909 WP_077918335.1 hypothetical protein -
LJF64_RS19785 (4115154) 4115154..4115868 - 715 Protein_3849 helix-turn-helix domain-containing protein -
LJF64_RS19790 (4116676) 4116676..4118142 - 1467 WP_000987828.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T221994 WP_000221343.1 NZ_CP085820:c4113120-4112836 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

>T221994 NZ_CP117650:c3706965-3706813 [Escherichia albertii]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT221994 WP_000885424.1 NZ_CP085820:c4113358-4113110 [Salmonella enterica subsp. enterica serovar Typhimurium]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT221994 NZ_CP117650:3707014-3707071 [Escherichia albertii]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References