Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3055581..3056201 Replicon chromosome
Accession NZ_CP085820
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain Wartortle

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag LJF64_RS14445 Protein ID WP_001280991.1
Coordinates 3055581..3055799 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag LJF64_RS14450 Protein ID WP_000344807.1
Coordinates 3055827..3056201 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF64_RS14405 (3050805) 3050805..3051374 + 570 WP_000779803.1 YbaY family lipoprotein -
LJF64_RS14410 (3051407) 3051407..3051796 - 390 WP_000961285.1 MGMT family protein -
LJF64_RS14420 (3052027) 3052027..3053577 - 1551 WP_000213139.1 EAL domain-containing protein -
LJF64_RS14425 (3053802) 3053802..3054062 + 261 WP_000801415.1 type B 50S ribosomal protein L31 -
LJF64_RS14430 (3054068) 3054068..3054208 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
LJF64_RS14435 (3054264) 3054264..3054734 - 471 WP_000136181.1 YlaC family protein -
LJF64_RS14440 (3054851) 3054851..3055402 - 552 WP_001278792.1 maltose O-acetyltransferase -
LJF64_RS14445 (3055581) 3055581..3055799 - 219 WP_001280991.1 HHA domain-containing protein Toxin
LJF64_RS14450 (3055827) 3055827..3056201 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
LJF64_RS14455 (3056697) 3056697..3059846 - 3150 WP_001132508.1 efflux RND transporter permease AcrB -
LJF64_RS14460 (3059869) 3059869..3061062 - 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T221993 WP_001280991.1 NZ_CP085820:c3055799-3055581 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T221993 NZ_CP117650:c2797994-2797842 [Escherichia albertii]
ATGCCGCAGAAATATAGATTGCTTTCTTTAATAGTGATTTGTTTCACGCTTTTATTTTTCACCTGGATGATAAGGGATTC
ACTGTGTGAATTGCATATTAAACAGGGGAGTTATGAGCTGGCGGCGTTTTTAGCCTGCAATCTGAAAGAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT221993 WP_000344807.1 NZ_CP085820:c3056201-3055827 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT221993 NZ_CP117650:2798051-2798099 [Escherichia albertii]
GCATAGAGGGGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References