Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2219404..2220185 Replicon chromosome
Accession NZ_CP085820
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain Wartortle

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag LJF64_RS10540 Protein ID WP_000626099.1
Coordinates 2219694..2220185 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag LJF64_RS10535 Protein ID WP_001110452.1
Coordinates 2219404..2219697 (+) Length 98 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF64_RS10505 (2215728) 2215728..2216633 + 906 WP_001268200.1 YjiK family protein -
LJF64_RS10510 (2216927) 2216927..2217196 - 270 WP_010989096.1 hypothetical protein -
LJF64_RS10515 (2217204) 2217204..2217419 - 216 WP_001595136.1 hypothetical protein -
LJF64_RS10520 (2217442) 2217442..2217729 - 288 WP_001269916.1 transcriptional regulator RtsB -
LJF64_RS10525 (2217726) 2217726..2218601 - 876 WP_000921674.1 AraC family transcriptional regulator -
LJF64_RS10530 (2218866) 2218866..2219087 - 222 WP_001576552.1 hypothetical protein -
LJF64_RS10535 (2219404) 2219404..2219697 + 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
LJF64_RS10540 (2219694) 2219694..2220185 + 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
LJF64_RS23705 (2220209) 2220209..2220286 + 78 Protein_2045 hypothetical protein -
LJF64_RS10550 (2220433) 2220433..2221185 - 753 Protein_2046 non-specific acid phosphatase -
LJF64_RS10555 (2221288) 2221288..2221362 - 75 Protein_2047 porin family protein -
LJF64_RS10560 (2222395) 2222395..2222772 - 378 WP_000916345.1 EthD family reductase -
LJF64_RS10565 (2222844) 2222844..2223176 + 333 WP_001165471.1 MerR family transcriptional regulator -
LJF64_RS10570 (2223267) 2223267..2223344 + 78 Protein_2050 helix-turn-helix domain-containing protein -
LJF64_RS10580 (2223615) 2223615..2224190 - 576 WP_001188509.1 transcriptional regulator -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(85-145)

Antitoxin

(14-88)


Sequences


Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T221987 WP_000626099.1 NZ_CP085820:2219694-2220185 [Salmonella enterica subsp. enterica serovar Typhimurium]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T221987 NZ_CP117650:c670145-669759 [Escherichia albertii]
ATGATTTGGGTCAGTGCACAGGAGGTCATTGCCTTCCACGATCGAATTTTGCAACGTTTTCCCGGTGTGGCGGGCCTGGC
CGACCCCGGCAGAGCACAGGCGCTGATTTATCGCGTGCAGAACCGTGTTCACTACGAGGGCGTTACTGACCTGTTTGAAC
TGGCAGCAACCTACTGGGTTGCCATCGCTCGCGGTCACATCTTTCATGATGGTAATAAACGTACCGCATTTTTCGTTACT
ATGACCTTTCTTTGGCGCAATGGCATCCGTATCCGTGACGTTGATAACTCGCTGGAGAACCTGACTGTCGAAGCGGCTAC
CGGAGAAAAAACGGTCGGTCAATTAGCGCGATGTTTACGTGAACGAGTGGATAGTTCCGGGAATTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT221987 WP_001110452.1 NZ_CP085820:2219404-2219697 [Salmonella enterica subsp. enterica serovar Typhimurium]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT221987 NZ_CP117650:c670363-670142 [Escherichia albertii]
ATGCAAACTTACACTTCCACACAAGCCAGAGCCAATATTGCCACTGTACTGGATACCGCGTTGAATGGTGAGCCAGTTGA
AATCACCCGTCGCGACGGCAGCTCTGCCGTGCTCATTAGTAAAGCCGCATTCGAGGCGTATCAAAATGCGAAACTGGACG
CGGAATTTGATGCCATCATGCAACGTCATGAACACACAATTGAAGCGTTGACTGATCGATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 7AK7


Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References