Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1495384..1496144 Replicon chromosome
Accession NZ_CP085820
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain Wartortle

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag LJF64_RS07185 Protein ID WP_000533909.1
Coordinates 1495384..1495869 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag LJF64_RS07190 Protein ID WP_000965886.1
Coordinates 1495857..1496144 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF64_RS07155 (1490452) 1490452..1491113 + 662 Protein_1396 OmpA family lipoprotein -
LJF64_RS07160 (1491332) 1491332..1492306 + 975 WP_000804674.1 glyoxylate/hydroxypyruvate reductase GhrB -
LJF64_RS07165 (1492356) 1492356..1493066 - 711 WP_000190524.1 DUF3053 domain-containing protein -
LJF64_RS07170 (1493506) 1493506..1493796 + 291 WP_000455790.1 HTH-type transcriptional regulator -
LJF64_RS07175 (1494085) 1494085..1494297 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
LJF64_RS07180 (1494473) 1494473..1495012 + 540 Protein_1401 copper-binding periplasmic metallochaperone CueP -
LJF64_RS07185 (1495384) 1495384..1495869 - 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
LJF64_RS07190 (1495857) 1495857..1496144 - 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
LJF64_RS07195 (1496322) 1496322..1496789 - 468 WP_000702452.1 GNAT family N-acetyltransferase -
LJF64_RS07200 (1496961) 1496961..1497236 - 276 Protein_1405 IS3 family transposase -
LJF64_RS07205 (1497418) 1497418..1499487 - 2070 WP_001291736.1 glycine--tRNA ligase subunit beta -
LJF64_RS07210 (1499497) 1499497..1500408 - 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
LJF64_RS07215 (1500547) 1500547..1500849 - 303 WP_000605590.1 YsaB family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T221984 WP_000533909.1 NZ_CP085820:c1495869-1495384 [Salmonella enterica subsp. enterica serovar Typhimurium]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T221984 NZ_CP117648:55079-55561 [Escherichia albertii]
ATGGAAATAAATGTCACCGCGCCGGCACTGCTGACGGATGAGCATATACTTCAGCCATTTGACTGTGGAAATGAGGTGCT
AAGTAACTGGTTACGTGGTCGGGCTATGAAAAACCAGATGCTCAATGCTTCCCGCACGTTCGTTATTTGTCTGGAGGGTA
CTTTACGTGTTGTGGGGTTCTACTCATTAGCTACGGGTTCCGTCACACATGCCGAGCTTGGGCGCAGTTTGCGGCATAAC
ATGCCCAGTCCTGTTCCTGTTGTTCTGTTAGGACGTCTGGCTGTCGATGTTTGTACCCAGGGACATGGTTTTGGTAAATG
GCTGCTAAGTGATGCTATTCACCGGGTTGCAAATCTGGCTGAACAGGTTGGTATTAAGGCTGTTATGGTCCATGCAATTG
ATGATGACGCCAGAGCGTTTTATGAGCGTTTTGGTTTTGTCCGGTCAGTTGTGGCACCCGACACCTTATTTTATAAAGTC
TGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT221984 WP_000965886.1 NZ_CP085820:c1496144-1495857 [Salmonella enterica subsp. enterica serovar Typhimurium]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT221984 NZ_CP117648:54786-55088 [Escherichia albertii]
ATGGAGGTTTTTATGTCTACGGCTGCAAGCGTCCGTAAAACACCGCGAGAAAATCAGATTAACATCCGGGCAACTGATGA
GGAACGAGCCGTTATTGATTATGCTGCGAGCCTGGTCAATAAGAACCGTACTGATTTCATCATTGAACTGGCTTACCAGG
AAGCTAAAAACATTATCCTGGATCAACGCTTATTTGTGCTGGATAACGAACGTTATGATTCGTTTATTACGCAACTGGAG
GCTCCTGTGCAGAATGCAGAAGGGCGTGAACGTCTGATGGCGGTAAAGCCTGAATGGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References