Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 863163..863823 Replicon chromosome
Accession NZ_CP085820
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain Wartortle

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag LJF64_RS04120 Protein ID WP_000244756.1
Coordinates 863163..863576 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag LJF64_RS04125 Protein ID WP_000351186.1
Coordinates 863557..863823 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF64_RS04100 (859104) 859104..860837 - 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -
LJF64_RS04105 (860843) 860843..861556 - 714 WP_000745625.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LJF64_RS04110 (861580) 861580..862476 - 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
LJF64_RS04115 (862589) 862589..863110 + 522 WP_001055885.1 flavodoxin FldB -
LJF64_RS04120 (863163) 863163..863576 - 414 WP_000244756.1 protein YgfX Toxin
LJF64_RS04125 (863557) 863557..863823 - 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
LJF64_RS04130 (864073) 864073..865053 + 981 WP_000874172.1 tRNA-modifying protein YgfZ -
LJF64_RS04135 (865169) 865169..865828 - 660 WP_000250289.1 hemolysin III family protein -
LJF64_RS04140 (865992) 865992..866303 - 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
LJF64_RS04145 (866462) 866462..867895 + 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T221982 WP_000244756.1 NZ_CP085820:c863576-863163 [Salmonella enterica subsp. enterica serovar Typhimurium]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T221982 NZ_CP117648:c42971-42573 [Escherichia albertii]
ATGCTGAAGTTTATGCTTGATACTAACATCTGCATTTTTACGATAAAGAACAAACCCGCCAGTGTCAGGGAACGTTTTAA
CCTGAATCAGGGGAGAATGTGTATCAGTTCGGTCACCCTGATGGAGCTGATATATGGTGCAGAAAAAAGCCAGATGCCTG
AACGTAATCTCGCTGTGATCGAGGGATTTGTTTCCCGCCTTGATGTTCTGGATTACGACGCCGCTGCAGCCACACATACC
GGCCAGATAAGGGCAGAACTTGCCCGTCAGGGACGTCCTGTCGGACCATTTGATCAAATGATCGCAGGCCATGCCCGCAG
CCGGGGGCTGATAGTTGTGACTAACAACATCCGGGAATTTGAACGTATGGACGGTCTGAGAATTGAAGACTGGAGCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT221982 WP_000351186.1 NZ_CP085820:c863823-863557 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT221982 NZ_CP117648:c43198-42971 [Escherichia albertii]
ATGGAAACCACCGTATTTCTCAGCAACCGCAGCCAGGCGGTCAGACTGCCAAAAGCGGTTGCATTGCCGGAAAACGTAAA
ACGCGTTGAAGTGATTGCTGTTGGACGAACCCGTATCATTACGCCAGCCGGAGAATCATGGGATGAATGGTTCGACGGAA
ACAGCGTCAGCGCCGATTTTATGGATAACCGGGAACAGCCCGGCATGCAGGAAAGGGAGTCATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References