Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2733684..2734344 Replicon chromosome
Accession NZ_CP085819
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain Blastoise

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag LJF65_RS12940 Protein ID WP_000244756.1
Coordinates 2733931..2734344 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag LJF65_RS12935 Protein ID WP_000351186.1
Coordinates 2733684..2733950 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF65_RS12915 (2729611) 2729611..2731044 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
LJF65_RS12920 (2731204) 2731204..2731515 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
LJF65_RS12925 (2731679) 2731679..2732338 + 660 WP_000250289.1 hemolysin III family protein -
LJF65_RS12930 (2732454) 2732454..2733434 - 981 WP_000874172.1 tRNA-modifying protein YgfZ -
LJF65_RS12935 (2733684) 2733684..2733950 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
LJF65_RS12940 (2733931) 2733931..2734344 + 414 WP_000244756.1 protein YgfX Toxin
LJF65_RS12945 (2734397) 2734397..2734918 - 522 WP_001055885.1 flavodoxin FldB -
LJF65_RS12950 (2735031) 2735031..2735927 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
LJF65_RS12955 (2735951) 2735951..2736664 + 714 WP_000745625.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LJF65_RS12960 (2736670) 2736670..2738403 + 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T221968 WP_000244756.1 NZ_CP085819:2733931-2734344 [Salmonella enterica subsp. enterica serovar Typhimurium]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T221968 NZ_CP117647:c262500-262198 [Escherichia albertii]
ATGACCAAAAAAATTAACATAAAGGATTTCAGGAATGCGTGGCTTGATGATTTTTTTGAATTTTCAACACCACACAAAAA
GATACCTTCTGATATTCATATTACATTGTTGCGGAAGCTGGATATTATCAATGCCGCAACTACCTGGAAGGACTTGAGAT
CACCACCAGGTAATCGGTATGAGGAATTGTCAGGGAAGCTAAACGGCTATTCATCAATAAGGGTGAATAATCAATATAGG
TTAATTTTTAAGTGGGTTAACGGAAAGGCCGAGGACTTGTATCTCGACCCTCACAAATACTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT221968 WP_000351186.1 NZ_CP085819:2733684-2733950 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT221968 NZ_CP117647:c262126-261788 [Escherichia albertii]
ATGAAACAGGCAACCAGAAAACCGACGACTGTAGGTGATATCCTGCTGTACGAATACCTGGAGCCGTTAGAGCTTAAGAT
CAACGAGTTAGCAGAAATACTTCATGTTCATCGCAACACCGTAAGTGCTCTTGTTAATAATAATCGTAAGCTAACGATGG
ATATGGCATATCGCCTGGCAAAAGCATTCGATACTTCTGTAGATTTTTGGATTAATCTTCAGACCGCAGTAGACCTGTGG
GAAGTTGAAAATGATATGCGCGTTCAGGAAGAGTTAAGCCGTATCACTACTGCTGAAGAATTTATTTCTCAGCGGAATCT
GAATAAAAAAGCAGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References