Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2101288..2102048 Replicon chromosome
Accession NZ_CP085819
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain Blastoise

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag LJF65_RS09875 Protein ID WP_000533909.1
Coordinates 2101563..2102048 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag LJF65_RS09870 Protein ID WP_000965886.1
Coordinates 2101288..2101575 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF65_RS09845 (2096583) 2096583..2096885 + 303 WP_000605590.1 YsaB family lipoprotein -
LJF65_RS09850 (2097024) 2097024..2097935 + 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
LJF65_RS09855 (2097945) 2097945..2100014 + 2070 WP_001291736.1 glycine--tRNA ligase subunit beta -
LJF65_RS09860 (2100196) 2100196..2100471 + 276 Protein_1909 IS3 family transposase -
LJF65_RS09865 (2100643) 2100643..2101110 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
LJF65_RS09870 (2101288) 2101288..2101575 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
LJF65_RS09875 (2101563) 2101563..2102048 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
LJF65_RS09880 (2102420) 2102420..2102959 - 540 Protein_1913 copper-binding periplasmic metallochaperone CueP -
LJF65_RS09885 (2103134) 2103134..2103346 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
LJF65_RS09890 (2103635) 2103635..2103925 - 291 WP_000455790.1 HTH-type transcriptional regulator -
LJF65_RS09895 (2104366) 2104366..2105076 + 711 WP_000190524.1 DUF3053 domain-containing protein -
LJF65_RS09900 (2105126) 2105126..2106100 - 975 WP_000804674.1 glyoxylate/hydroxypyruvate reductase GhrB -
LJF65_RS09905 (2106319) 2106319..2106980 - 662 Protein_1918 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T221965 WP_000533909.1 NZ_CP085819:2101563-2102048 [Salmonella enterica subsp. enterica serovar Typhimurium]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T221965 NZ_CP117644:92962-93240 [Escherichia albertii]
ATGGAGATATTCTGGACCATGCTGGCCAGCCTGGACCGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGATGGC
CGCCATTGAACTGGACGAACGGATTGGTTATTCCGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGCCGTG
TGGAAGGCACCCGGGAACTGGTTATTCACCCCCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTGTAT
ATCCTGCGCGTGTTGCATACCGCACAGAAGTGGCCATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT221965 WP_000965886.1 NZ_CP085819:2101288-2101575 [Salmonella enterica subsp. enterica serovar Typhimurium]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT221965 NZ_CP117644:92693-92962 [Escherichia albertii]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCGTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGTCAGACCGTTGAACGGCAGCATAATACCTGGTTCCATGACCAGGTTG
AGGCAGGACGTCAGCAACTCGGGCGCGGTGATATGCTTCCCCATGACATGGTCGAATCATCTGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAGGTCGCCGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References