Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1377260..1378041 Replicon chromosome
Accession NZ_CP085819
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain Blastoise

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag LJF65_RS06520 Protein ID WP_000626099.1
Coordinates 1377260..1377751 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag LJF65_RS06525 Protein ID WP_001110452.1
Coordinates 1377748..1378041 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF65_RS06480 (1373255) 1373255..1373830 + 576 WP_001188509.1 transcriptional regulator -
LJF65_RS06490 (1374101) 1374101..1374178 - 78 Protein_1263 helix-turn-helix domain-containing protein -
LJF65_RS06495 (1374269) 1374269..1374601 - 333 WP_001165471.1 MerR family transcriptional regulator -
LJF65_RS06500 (1374673) 1374673..1375050 + 378 WP_000916345.1 EthD family reductase -
LJF65_RS06505 (1376083) 1376083..1376157 + 75 Protein_1266 porin family protein -
LJF65_RS06510 (1376260) 1376260..1377012 + 753 Protein_1267 non-specific acid phosphatase -
LJF65_RS23730 (1377159) 1377159..1377212 - 54 WP_231236156.1 SdiA-regulated domain-containing protein -
LJF65_RS06520 (1377260) 1377260..1377751 - 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
LJF65_RS06525 (1377748) 1377748..1378041 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
LJF65_RS06530 (1378358) 1378358..1378579 + 222 WP_001576552.1 hypothetical protein -
LJF65_RS06535 (1378844) 1378844..1379719 + 876 WP_000921674.1 AraC family transcriptional regulator -
LJF65_RS06540 (1379716) 1379716..1380003 + 288 WP_001269916.1 transcriptional regulator RtsB -
LJF65_RS06545 (1380026) 1380026..1380241 + 216 WP_001595136.1 hypothetical protein -
LJF65_RS06550 (1380249) 1380249..1380518 + 270 WP_010989096.1 hypothetical protein -
LJF65_RS06555 (1380812) 1380812..1381717 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T221962 WP_000626099.1 NZ_CP085819:c1377751-1377260 [Salmonella enterica subsp. enterica serovar Typhimurium]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T221962 NZ_CP117643:4329436-4329777 [Escherichia albertii]
ATGAAAATTATTCCTGCAACGACGCTGCGGGCGACGACGTCATATCTGTCGCCCGTCGTGGTCTGGCAAACATTACTGGC
CCGCCTGCTGGAGCAGCACTACGGACTGAACCTTAATGACACACCATTCAACAATGAAAAGGTGATTCAGGAACACATAG
ACGCCGGGATCACTCTGGTTGATGCCGTCAATTTTCTGGTGGAGAAGTACGAATTGATCCGTATCGACAGGAAAGGATTT
AGCTGGCAGGAACAGACGCCTTATCTTCGTGCGGTCGATATTTTGCGGGCGAGGCAGGCTACAGGTCAGCTGCGTCGCTG
CCATAACACCACGGCACGGTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT221962 WP_001110452.1 NZ_CP085819:c1378041-1377748 [Salmonella enterica subsp. enterica serovar Typhimurium]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT221962 NZ_CP117643:4329070-4329405 [Escherichia albertii]
ATGCTGCAAAAGGACAAGGTCATGCAACAAGAATGGGGGCTTCCCTGTACCGTTACACCACGCTTCACTGCACGACTGGT
ACAGGAAAGACATAACCTGCATTACCTGGCTGATCGGGCCGCAATCACCGGGAAATTCAGCTCCCCGGATCTGCTGCATA
TCGACCAGGCTTTTCCGGTGCTGATGAAACAACTGGAGCTGAAACTGGCTGACGGTGAACTCTCCCCCTGCCAACAACGT
ACCGTCACGCTATACGCCAAAGGACTAACCTGCGAAGCCGATACGCTGGGTTCCTGTGGTTACGTCTATATCGCTATTTA
TCCCACTCAACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References