221955

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4365831..4366591 Replicon chromosome
Accession NZ_CP085818
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Clefairy

Toxin (Protein)


Gene name tacT Uniprot ID A0A1R2W0C7
Locus tag LJF66_RS21325 Protein ID WP_000533912.1
Coordinates 4365831..4366316 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag LJF66_RS21330 Protein ID WP_000965886.1
Coordinates 4366304..4366591 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF66_RS21295 (4360903) 4360903..4361565 + 663 WP_000747548.1 OmpA family lipoprotein -
LJF66_RS21300 (4361784) 4361784..4362758 + 975 WP_000804678.1 glyoxylate/hydroxypyruvate reductase GhrB -
LJF66_RS21305 (4362808) 4362808..4363518 - 711 WP_000190524.1 DUF3053 domain-containing protein -
LJF66_RS21310 (4363957) 4363957..4364247 + 291 WP_000455790.1 HTH-type transcriptional regulator -
LJF66_RS21315 (4364535) 4364535..4364747 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
LJF66_RS21320 (4364921) 4364921..4365460 + 540 WP_000047147.1 copper-binding periplasmic metallochaperone CueP -
LJF66_RS21325 (4365831) 4365831..4366316 - 486 WP_000533912.1 GNAT family N-acetyltransferase Toxin
LJF66_RS21330 (4366304) 4366304..4366591 - 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
LJF66_RS21335 (4366769) 4366769..4367236 - 468 WP_000702452.1 GNAT family N-acetyltransferase -
LJF66_RS21340 (4367408) 4367408..4367806 - 399 Protein_4155 IS3 family transposase -
LJF66_RS21345 (4368196) 4368196..4370265 - 2070 WP_001291741.1 glycine--tRNA ligase subunit beta -
LJF66_RS21350 (4370275) 4370275..4371186 - 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17731.46 Da        Isoelectric Point: 9.8719

>T221955 WP_000533912.1 NZ_CP085818:c4366316-4365831 [Salmonella enterica subsp. enterica serovar Enteritidis]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEVTGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T221955 NZ_CP117643:2141545-2141646 [Escherichia albertii]
GCAAGGCAACTGAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAAAACA
GGAATCGTTTTCGGTCTTTTTT

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT221955 WP_000965886.1 NZ_CP085818:c4366591-4366304 [Salmonella enterica subsp. enterica serovar Enteritidis]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT221955 NZ_CP117643:c2141646-2141417 [Escherichia albertii]
AAAAAAGACCGAAAACGATTCCTGTTTTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATT
AATGCAGGCTCAGTTGCCTTGCTCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCGTACAAAATGGTCAGTAA
AAAGCGCGTCGGCCATCGTCTTAAATGTTAAAAACCGCCCGTTCTGGTGAAAGAACTGTGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1R2W0C7

Antitoxin

Source ID Structure
AlphaFold DB A0A3V2JDX2

References