Detailed information of TA system TA221939

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 1123059..1123679
• Replicon: chromosome
• Accession: NZ_CP085818
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain Clefairy

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: V1H8E6
• Locus tag: LJF66_RS05230
• Protein ID: WP_001280991.1
• Coordinates: 1123059..1123277 (-)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: V1H4V6
• Locus tag: LJF66_RS05235
• Protein ID: WP_000344807.1
• Coordinates: 1123305..1123679 (-)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJF66_RS05190 (1118282)	1118282..1118851	+	570	WP_000779802.1	YbaY family lipoprotein	-
LJF66_RS05195 (1118884)	1118884..1119273	-	390	WP_000961287.1	MGMT family protein	-
LJF66_RS05205 (1119504)	1119504..1121054	-	1551	WP_000213140.1	EAL domain-containing protein	-
LJF66_RS05210 (1121279)	1121279..1121539	+	261	WP_000801415.1	type B 50S ribosomal protein L31	-
LJF66_RS05215 (1121545)	1121545..1121685	+	141	WP_001197749.1	type B 50S ribosomal protein L36	-
LJF66_RS05220 (1121741)	1121741..1122211	-	471	WP_000136183.1	YlaC family protein	-
LJF66_RS05225 (1122329)	1122329..1122880	-	552	WP_001278793.1	maltose O-acetyltransferase	-
LJF66_RS05230 (1123059)	1123059..1123277	-	219	WP_001280991.1	HHA domain-containing protein	Toxin
LJF66_RS05235 (1123305)	1123305..1123679	-	375	WP_000344807.1	Hha toxicity modulator TomB	Antitoxin
LJF66_RS05240 (1124175)	1124175..1127324	-	3150	WP_001132508.1	efflux RND transporter permease AcrB	-
LJF66_RS05245 (1127347)	1127347..1128540	-	1194	WP_001039202.1	multidrug efflux RND transporter periplasmic adaptor subunit AcrA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-116)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8613.97 Da
• Isoelectric Point: 8.9008

>T221939 WP_001280991.1 NZ_CP085818:c1123277-1123059 [Salmonella enterica subsp. enterica serovar Enteritidis]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Nucleotide

• Length: 219 bp

>T221939 NZ_CP117637:2510280-2510666 [Escherichia albertii]
ATGATTTGGGTCAGTGCACAGGAGGTCATTGCCTTCCACGCTCGAATTTTGCAACGTTTTCCCGGTGTGGCGGGCCTGAC
TGACCCCGGCAGAGCACAGGCGTTGATTTATCGCGTGCAGAATCGTGTTCACTACGAGGGCGTTACTGACCTGTTTGAAC
TGGCAGCAACCTACTGGGTTGCCATCGCTCGCGGTCACATCTTTCATGATGGTAATAAACGTACCGCATTTTTCGTTACT
ATGACCTTTCTTTGGCGCAATGGCACCCGTATCCGTGACGTTGATAACTCGCTGGAGAATCTGACTGTCGAAGCGGCTAC
CGGAGAAAAAACGGTCGGTCAATTAGCGCGATGTTTACGTGAACGAGTGGATAGTTCCGGGAATTAA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 14453.27 Da
• Isoelectric Point: 5.1444

>AT221939 WP_000344807.1 NZ_CP085818:c1123679-1123305 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Nucleotide

• Length: 375 bp

>AT221939 NZ_CP117637:2510062-2510283 [Escherichia albertii]
ATGCAAACTTACACTTCCACACAAGCCAGAGCCAATATTGCCACTGTACTGGATACCGCGTTGAATGGTGAGCCAGTTGA
AATCACCCGTCGCGACGGCAGCTCTGCCGTGCTCATTAGTAAAGCCGCATTCGAGGCGTATCAAAATGCGAAACTGGACG
CGGAATTTGATGCCATCATGCAACGTCATGAACACACAATTGAAGCGTTGACTGATCGATGA

Structures

Toxin

• PDB: 4ICG

Antitoxin

• AlphaFold DB: A0A5I5FGI0