Detailed information of TA system TA221933

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 462061..462577
• Replicon: chromosome
• Accession: NZ_CP085818
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain Clefairy

Toxin (Protein)

• Gene name: relE
• Uniprot ID: B5R9I9
• Locus tag: LJF66_RS02150
• Protein ID: WP_000220582.1
• Coordinates: 462293..462577 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: V7ISI8
• Locus tag: LJF66_RS02145
• Protein ID: WP_000212724.1
• Coordinates: 462061..462303 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJF66_RS02125 (457081)	457081..458214	+	1134	WP_000459957.1	amidohydrolase/deacetylase family metallohydrolase	-
LJF66_RS02130 (458198)	458198..459316	+	1119	WP_001139169.1	DgaE family pyridoxal phosphate-dependent ammonia lyase	-
LJF66_RS02135 (459313)	459313..460053	+	741	WP_000779259.1	KDGP aldolase family protein	-
LJF66_RS02140 (460070)	460070..461983	+	1914	WP_001212142.1	BglG family transcription antiterminator	-
LJF66_RS02145 (462061)	462061..462303	+	243	WP_000212724.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LJF66_RS02150 (462293)	462293..462577	+	285	WP_000220582.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LJF66_RS02155 (462581)	462581..463045	-	465	WP_001268859.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
LJF66_RS02160 (463167)	463167..465305	-	2139	WP_000187818.1	anaerobic ribonucleoside-triphosphate reductase	-
LJF66_RS02165 (465714)	465714..467366	-	1653	WP_000155048.1	alpha,alpha-phosphotrehalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10912.66 Da
• Isoelectric Point: 9.6743

>T221933 WP_000220582.1 NZ_CP085818:462293-462577 [Salmonella enterica subsp. enterica serovar Enteritidis]
MTYELEFDPRALKEWHKLGDTVQAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Nucleotide

• Length: 285 bp

>T221933 NZ_CP117637:285518-286045 [Escherichia albertii]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTGGTTCGTCAACATCGCAATAAAATTTTGCGAGCGTATATCCTTTGTAGCAACACTC
CAGAATGTCAGGTCCTGGGATATTACACATTATCCGGCAGTTGTTTTGAACGAGCCGCACTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTCACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCATTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCTCTGAATGAAAAAGCCCATACGTTTTATCTGTCGCTGGGCTTTATCCCGTTGGTTGGAGAAAACGAAAATGCGTTA
TTTTTCCCAACTAAATCCATTGAACTGCTTTTTACACAGAGCGATTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8961.34 Da
• Isoelectric Point: 5.0651

>AT221933 WP_000212724.1 NZ_CP085818:462061-462303 [Salmonella enterica subsp. enterica serovar Enteritidis]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Nucleotide

• Length: 243 bp

>AT221933 NZ_CP117637:285245-285511 [Escherichia albertii]
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCTGCGAT
ATCTAATCAATCCGTCAGCCAATTTATGTTGAACTGCGCTTCGCAGCGAGCTGCGGAAGTGATTGAACAGCATCGGCGGA
TGATTCTCAATGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGTTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA

Structures

Toxin

• AlphaFold DB: A0A656ILJ8

Antitoxin

• AlphaFold DB: A0A5H5JRI5