Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 354900..355681 | Replicon | chromosome |
| Accession | NZ_CP085818 | ||
| Organism | Salmonella enterica subsp. enterica serovar Enteritidis strain Clefairy | ||
Toxin (Protein)
| Gene name | TacT2 | Uniprot ID | B5R980 |
| Locus tag | LJF66_RS01575 | Protein ID | WP_000626100.1 |
| Coordinates | 355190..355681 (+) | Length | 164 a.a. |
Antitoxin (Protein)
| Gene name | TacA2 | Uniprot ID | B5R979 |
| Locus tag | LJF66_RS01570 | Protein ID | WP_001110452.1 |
| Coordinates | 354900..355193 (+) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LJF66_RS01535 (350947) | 350947..351852 | + | 906 | WP_001268200.1 | YjiK family protein | - |
| LJF66_RS01540 (352146) | 352146..352277 | - | 132 | Protein_289 | hypothetical protein | - |
| LJF66_RS01545 (352389) | 352389..352637 | - | 249 | Protein_290 | Ig-like domain-containing protein | - |
| LJF66_RS01550 (352636) | 352636..352944 | + | 309 | WP_072095651.1 | ABC transporter ATP-binding protein | - |
| LJF66_RS01555 (352937) | 352937..353224 | - | 288 | WP_001541332.1 | transcriptional regulator RtsB | - |
| LJF66_RS01560 (353221) | 353221..354096 | - | 876 | WP_000921676.1 | AraC family transcriptional regulator | - |
| LJF66_RS01565 (354362) | 354362..354583 | - | 222 | WP_001576552.1 | hypothetical protein | - |
| LJF66_RS01570 (354900) | 354900..355193 | + | 294 | WP_001110452.1 | DUF1778 domain-containing protein | Antitoxin |
| LJF66_RS01575 (355190) | 355190..355681 | + | 492 | WP_000626100.1 | GNAT family N-acetyltransferase | Toxin |
| LJF66_RS01580 (355929) | 355929..356681 | - | 753 | WP_000842433.1 | non-specific acid phosphatase | - |
| LJF66_RS01585 (356781) | 356781..356858 | - | 78 | Protein_298 | porin family protein | - |
| LJF66_RS01590 (357238) | 357238..357312 | + | 75 | Protein_299 | helix-turn-helix domain-containing protein | - |
| LJF66_RS01600 (357583) | 357583..358158 | - | 576 | WP_001188509.1 | transcriptional regulator | - |
| LJF66_RS01605 (358195) | 358195..359898 | - | 1704 | WP_000068885.1 | protein-disulfide reductase DsbD | - |
| LJF66_RS01610 (359874) | 359874..360221 | - | 348 | WP_000887832.1 | divalent cation tolerance protein CutA | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 164 a.a. Molecular weight: 17645.45 Da Isoelectric Point: 7.7297
>T221932 WP_000626100.1 NZ_CP085818:355190-355681 [Salmonella enterica subsp. enterica serovar Enteritidis]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV
Download Length: 492 bp
>T221932 NZ_CP117637:c234389-234087 [Escherichia albertii]
ATGACCAAAAAAATTAACATAAAGGATTTCAGGGATGCGTGGCTTGATGATTTTTTTGAATTTTCAACACCACACAAAAA
GATACCTTCTGATATTCATATTACATTGTTGCGGAAGCTGGATATTATCAATGCCGCAACTACCTGGAAGGACTTGAGAT
CACCACCAGGTAATCGGTATGAGGAATTGTCAGGGAAGCTAAACGGCTATTCATCAATAAGGGTGAATAATCAATATAGG
TTAATTTTTAAGTGGGTTAACGGAAAGGCCGAGGACTTGTATCTCGACCCTCACAAATACTAA
ATGACCAAAAAAATTAACATAAAGGATTTCAGGGATGCGTGGCTTGATGATTTTTTTGAATTTTCAACACCACACAAAAA
GATACCTTCTGATATTCATATTACATTGTTGCGGAAGCTGGATATTATCAATGCCGCAACTACCTGGAAGGACTTGAGAT
CACCACCAGGTAATCGGTATGAGGAATTGTCAGGGAAGCTAAACGGCTATTCATCAATAAGGGTGAATAATCAATATAGG
TTAATTTTTAAGTGGGTTAACGGAAAGGCCGAGGACTTGTATCTCGACCCTCACAAATACTAA
Antitoxin
Download Length: 98 a.a. Molecular weight: 10977.61 Da Isoelectric Point: 8.6141
>AT221932 WP_001110452.1 NZ_CP085818:354900-355193 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
Download Length: 294 bp
>AT221932 NZ_CP117637:c234015-233677 [Escherichia albertii]
ATGAAACAGGCAACCAGAAAACCGACGACTGTAGGTGATATCCTGCTGTACGAATACCTGGAGCCGTTAGAGCTTAAGAT
CAACGAGTTAGCAGAAATACTTCATGTTCATCGCAACACCGTAAGTGCTCTTGTCAATAATAATCGTAAGCTAACGATGG
ATATGGCATATCGCCTGGCAAAAGCATTCGATACTTCTGTAGATTTTTGGATTAATCTTCAGACCGCAGTAGACCTGTGG
GAAGTTGAAAATGATATGCGCGTTCAGGAAGAGTTAAGCCGTATCACTACTGCTGAAGAATTTATTTCTCAGCGGAATCT
GAATAAAAAAGCAGCCTGA
ATGAAACAGGCAACCAGAAAACCGACGACTGTAGGTGATATCCTGCTGTACGAATACCTGGAGCCGTTAGAGCTTAAGAT
CAACGAGTTAGCAGAAATACTTCATGTTCATCGCAACACCGTAAGTGCTCTTGTCAATAATAATCGTAAGCTAACGATGG
ATATGGCATATCGCCTGGCAAAAGCATTCGATACTTCTGTAGATTTTTGGATTAATCTTCAGACCGCAGTAGACCTGTGG
GAAGTTGAAAATGATATGCGCGTTCAGGAAGAGTTAAGCCGTATCACTACTGCTGAAGAATTTATTTCTCAGCGGAATCT
GAATAAAAAAGCAGCCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A656IQ80 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5I1DGA4 |