Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4356706..4357366 Replicon chromosome
Accession NZ_CP085817
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Clefable

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag LJF67_RS21230 Protein ID WP_000244756.1
Coordinates 4356706..4357119 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag LJF67_RS21235 Protein ID WP_000351186.1
Coordinates 4357100..4357366 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF67_RS21210 (4352647) 4352647..4354380 - 1734 WP_000813389.1 single-stranded-DNA-specific exonuclease RecJ -
LJF67_RS21215 (4354386) 4354386..4355099 - 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LJF67_RS21220 (4355123) 4355123..4356019 - 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
LJF67_RS21225 (4356132) 4356132..4356653 + 522 WP_001055885.1 flavodoxin FldB -
LJF67_RS21230 (4356706) 4356706..4357119 - 414 WP_000244756.1 protein YgfX Toxin
LJF67_RS21235 (4357100) 4357100..4357366 - 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
LJF67_RS21240 (4357616) 4357616..4358596 + 981 WP_000874176.1 tRNA-modifying protein YgfZ -
LJF67_RS21245 (4358712) 4358712..4359371 - 660 WP_000250289.1 hemolysin III family protein -
LJF67_RS21250 (4359535) 4359535..4359846 - 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
LJF67_RS21255 (4360004) 4360004..4361437 + 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T221929 WP_000244756.1 NZ_CP085817:c4357119-4356706 [Salmonella enterica subsp. enterica serovar Enteritidis]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T221929 NZ_CP117631:83897-84046 [Escherichia albertii]
ATGACGAAATATACCCTAATTGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT221929 WP_000351186.1 NZ_CP085817:c4357366-4357100 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT221929 NZ_CP117631:c83853-83792 [Escherichia albertii]
TTAAGGTACTTCATGCAGGCCTCACGAGTTAATGGATTAACAAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References