Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1738664..1739284 Replicon chromosome
Accession NZ_CP085817
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Clefable

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag LJF67_RS08160 Protein ID WP_001280991.1
Coordinates 1738664..1738882 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag LJF67_RS08165 Protein ID WP_000344807.1
Coordinates 1738910..1739284 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF67_RS08120 (1733887) 1733887..1734456 + 570 WP_000779802.1 YbaY family lipoprotein -
LJF67_RS08125 (1734489) 1734489..1734878 - 390 WP_000961287.1 MGMT family protein -
LJF67_RS08135 (1735109) 1735109..1736659 - 1551 WP_000213140.1 EAL domain-containing protein -
LJF67_RS08140 (1736884) 1736884..1737144 + 261 WP_000801415.1 type B 50S ribosomal protein L31 -
LJF67_RS08145 (1737150) 1737150..1737290 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
LJF67_RS08150 (1737346) 1737346..1737816 - 471 WP_000136183.1 YlaC family protein -
LJF67_RS08155 (1737934) 1737934..1738485 - 552 WP_001278793.1 maltose O-acetyltransferase -
LJF67_RS08160 (1738664) 1738664..1738882 - 219 WP_001280991.1 HHA domain-containing protein Toxin
LJF67_RS08165 (1738910) 1738910..1739284 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
LJF67_RS08170 (1739780) 1739780..1742929 - 3150 WP_001132508.1 efflux RND transporter permease AcrB -
LJF67_RS08175 (1742952) 1742952..1744145 - 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T221916 WP_001280991.1 NZ_CP085817:c1738882-1738664 [Salmonella enterica subsp. enterica serovar Enteritidis]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T221916 NZ_CP117628:c1101289-1101071 [Escherichia albertii]
ATGTCCGATAAACCTTTAACAAAAACCGATTATTTGATGCGTCTGCGTCGTTGCCAGACAATTGACACACTGGAACGTGT
TATCGAGAAAAATAAATATGAATTATCAGATAATGAATTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTTGCAGAGC
TGACTATGAATAAGCTATATGACAAGATCCCTTCCTCAGTGTGGAAATTCATTCGGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT221916 WP_000344807.1 NZ_CP085817:c1739284-1738910 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT221916 NZ_CP117628:c1101689-1101315 [Escherichia albertii]
ATGGATGAATACTCACCAAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGTAACCATGGCTGGGTAAATGACCCAACCTCGGCAATCAATCTACAGCTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAACAGATTGATGAATATCTG
GACGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAACCGATT
GTTCCGTTGCTTTGTTAACGCCACCAAAGCGAATCCTGCAAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References