Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 1163178..1163754 Replicon chromosome
Accession NZ_CP085817
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Clefable

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag LJF67_RS05510 Protein ID WP_001131963.1
Coordinates 1163178..1163465 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag LJF67_RS05515 Protein ID WP_000063142.1
Coordinates 1163452..1163754 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF67_RS05495 (1160038) 1160038..1161342 - 1305 WP_000863534.1 type I restriction-modification protein specificity subunit -
LJF67_RS05500 (1161332) 1161332..1161511 - 180 Protein_1058 DNA methyltransferase -
LJF67_RS05505 (1161505) 1161505..1162761 - 1257 Protein_1059 NERD domain-containing protein/DEAD/DEAH box helicase -
LJF67_RS05510 (1163178) 1163178..1163465 + 288 WP_001131963.1 BrnT family toxin Toxin
LJF67_RS05515 (1163452) 1163452..1163754 + 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
LJF67_RS05520 (1163829) 1163829..1164785 - 957 WP_000187843.1 GTPase -
LJF67_RS05525 (1164796) 1164796..1164999 - 204 WP_000460616.1 YbdD/YjiX family protein -
LJF67_RS05530 (1165094) 1165094..1167244 - 2151 WP_000379928.1 pyruvate/proton symporter BtsT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T221912 WP_001131963.1 NZ_CP085817:1163178-1163465 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

>T221912 NZ_CP117624:34706-34987 [Escherichia albertii]
ATGACCTATGAACTGGCTTTTGACCGTAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAACTGGCAGAACGGCTGGAAAATCCACGCGTACCCGCAGCCCGGTTACATGGTCATGCTGATCGCTATAAAATCA
AACTTCGTGCATCTGGCTACAGACTTGTATACCAAGTCATTGATGAGAAAGTCGTTTTACTCGTTATTGCCGTTGGAAGA
AGGGAAAGCAGCGAAGTCTATCAGATCGCAGATTTGCGCTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT221912 WP_000063142.1 NZ_CP085817:1163452-1163754 [Salmonella enterica subsp. enterica serovar Enteritidis]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp

>AT221912 NZ_CP117624:34465-34716 [Escherichia albertii]
ATGAGCTATCAAATTCTGACAACCACAGCGGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACCGTAGCTGAAGG
TGAAGGGGACGCTGTTGCGATCCTGAACCGAAACGAACCGGCGTTCTATTGCGTTCCACCAAAACTTTACGCCTACTATC
GGGAACTCGCTGAAGATGCTGAGTTAAACGCTGTTGCTGATGAGCGCATGAAAAACCCGGAAATTGTGAAGGTTAACCTG
GATGACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
PDB 7VD7
AlphaFold DB A0A4D6PB01

References