Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1118943..1119493 Replicon chromosome
Accession NZ_CP085817
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Clefable

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag LJF67_RS05300 Protein ID WP_001199743.1
Coordinates 1119185..1119493 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7RP97
Locus tag LJF67_RS05295 Protein ID WP_001118105.1
Coordinates 1118943..1119182 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF67_RS05260 (1114382) 1114382..1115413 - 1032 WP_000453347.1 L-idonate 5-dehydrogenase -
LJF67_RS05265 (1115630) 1115630..1116160 + 531 WP_000896758.1 gluconokinase -
LJF67_RS05270 (1116188) 1116188..1117207 - 1020 WP_000152558.1 NAD(P)-dependent alcohol dehydrogenase -
LJF67_RS05285 (1117964) 1117964..1118509 + 546 WP_223151225.1 helix-turn-helix domain-containing protein -
LJF67_RS05290 (1118586) 1118586..1118834 + 249 WP_000168388.1 ribbon-helix-helix domain-containing protein -
LJF67_RS05295 (1118943) 1118943..1119182 + 240 WP_001118105.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
LJF67_RS05300 (1119185) 1119185..1119493 + 309 WP_001199743.1 CcdB family protein Toxin
LJF67_RS05305 (1119899) 1119899..1120039 + 141 Protein_1019 Arm DNA-binding domain-containing protein -
LJF67_RS05310 (1120071) 1120071..1121204 - 1134 Protein_1020 IS3 family transposase -
LJF67_RS05315 (1121527) 1121527..1122057 + 531 WP_000909461.1 SEF14 fimbria major subunit SefA -
LJF67_RS05320 (1122179) 1122179..1122919 + 741 WP_001676217.1 SEF14/SEF18 fimbria chaperone SefB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 1118009..1121112 3103


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T221911 WP_001199743.1 NZ_CP085817:1119185-1119493 [Salmonella enterica subsp. enterica serovar Enteritidis]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

>T221911 NZ_CP117623:63707-64087 [Escherichia albertii]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAACCGCTACGGCGGCCTGCCGGGAATGTC
AGATCCGGGTAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGTTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGGGCTGCGACCGG
AGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCCGCGGAGTAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8719.90 Da        Isoelectric Point: 6.4633

>AT221911 WP_001118105.1 NZ_CP085817:1118943-1119182 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp

>AT221911 NZ_CP117623:63486-63707 [Escherichia albertii]
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAAGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A5H9SZK8

References