Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1077852..1078368 Replicon chromosome
Accession NZ_CP085817
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Clefable

Toxin (Protein)


Gene name relE Uniprot ID B5R9I9
Locus tag LJF67_RS05080 Protein ID WP_000220582.1
Coordinates 1078084..1078368 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag LJF67_RS05075 Protein ID WP_000212724.1
Coordinates 1077852..1078094 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF67_RS05055 (1072872) 1072872..1074005 + 1134 WP_000459957.1 amidohydrolase/deacetylase family metallohydrolase -
LJF67_RS05060 (1073989) 1073989..1075107 + 1119 WP_001139169.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
LJF67_RS05065 (1075104) 1075104..1075844 + 741 WP_000779259.1 KDGP aldolase family protein -
LJF67_RS05070 (1075861) 1075861..1077774 + 1914 WP_001212142.1 BglG family transcription antiterminator -
LJF67_RS05075 (1077852) 1077852..1078094 + 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LJF67_RS05080 (1078084) 1078084..1078368 + 285 WP_000220582.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LJF67_RS05085 (1078372) 1078372..1078836 - 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LJF67_RS05090 (1078958) 1078958..1081096 - 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
LJF67_RS05095 (1081505) 1081505..1083157 - 1653 WP_000155048.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10912.66 Da        Isoelectric Point: 9.6743

>T221910 WP_000220582.1 NZ_CP085817:1078084-1078368 [Salmonella enterica subsp. enterica serovar Enteritidis]
MTYELEFDPRALKEWHKLGDTVQAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T221910 NZ_CP117622:97349-97498 [Escherichia albertii]
ATGACGAAATATACCCTAATTGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT221910 WP_000212724.1 NZ_CP085817:1077852-1078094 [Salmonella enterica subsp. enterica serovar Enteritidis]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT221910 NZ_CP117622:c97305-97244 [Escherichia albertii]
TTAAGGTACTTCATGCAGGCCTCACGAGTTAATGGATTAACAAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656ILJ8

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References