Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 970691..971472 Replicon chromosome
Accession NZ_CP085817
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Clefable

Toxin (Protein)


Gene name TacT2 Uniprot ID B5R980
Locus tag LJF67_RS04505 Protein ID WP_000626100.1
Coordinates 970981..971472 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag LJF67_RS04500 Protein ID WP_001110452.1
Coordinates 970691..970984 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF67_RS04465 (966738) 966738..967643 + 906 WP_001268200.1 YjiK family protein -
LJF67_RS04470 (967937) 967937..968068 - 132 Protein_859 hypothetical protein -
LJF67_RS04475 (968180) 968180..968428 - 249 Protein_860 Ig-like domain-containing protein -
LJF67_RS04480 (968427) 968427..968735 + 309 WP_072095651.1 ABC transporter ATP-binding protein -
LJF67_RS04485 (968728) 968728..969015 - 288 WP_001541332.1 transcriptional regulator RtsB -
LJF67_RS04490 (969012) 969012..969887 - 876 WP_000921676.1 AraC family transcriptional regulator -
LJF67_RS04495 (970153) 970153..970374 - 222 WP_001576552.1 hypothetical protein -
LJF67_RS04500 (970691) 970691..970984 + 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
LJF67_RS04505 (970981) 970981..971472 + 492 WP_000626100.1 GNAT family N-acetyltransferase Toxin
LJF67_RS04510 (971720) 971720..972472 - 753 WP_000842433.1 non-specific acid phosphatase -
LJF67_RS04515 (972572) 972572..972649 - 78 Protein_868 porin family protein -
LJF67_RS04520 (973029) 973029..973103 + 75 Protein_869 helix-turn-helix domain-containing protein -
LJF67_RS04530 (973374) 973374..973949 - 576 WP_001188509.1 transcriptional regulator -
LJF67_RS04535 (973986) 973986..975689 - 1704 WP_000068885.1 protein-disulfide reductase DsbD -
LJF67_RS04540 (975665) 975665..976012 - 348 WP_000887832.1 divalent cation tolerance protein CutA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17645.45 Da        Isoelectric Point: 7.7297

>T221909 WP_000626100.1 NZ_CP085817:970981-971472 [Salmonella enterica subsp. enterica serovar Enteritidis]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T221909 NZ_CP117621:c9620-9315 [Escherichia albertii]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTCCAGAGTGACATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCCCGCCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGTATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGGGAAAATGACATCAAAAATGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT221909 WP_001110452.1 NZ_CP085817:970691-970984 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT221909 NZ_CP117621:c9840-9622 [Escherichia albertii]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGCTGCTCAAGGCGTATGACGTGAATATCTCCGGTCT
GGTCAGTACGACCATGCAGAACGAAGCCCGGCGACTGCGCGCTGAACGCTGGCAGGCTGAAAATCAGGAAGGGATGGCAG
AGGTCGCTAGGTTTATTGAAATGAACGGCTCTTTTGCCGATGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IQ80

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References