Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 4558310..4558896 Replicon chromosome
Accession NZ_CP085816
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Slowpoke

Toxin (Protein)


Gene name doc Uniprot ID A0A3V9X0E4
Locus tag LJF68_RS22210 Protein ID WP_000174964.1
Coordinates 4558528..4558896 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID V7IU48
Locus tag LJF68_RS22205 Protein ID WP_001522145.1
Coordinates 4558310..4558531 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF68_RS22180 (4553331) 4553331..4554440 + 1110 WP_000822978.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
LJF68_RS22185 (4554500) 4554500..4555426 + 927 WP_000003007.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
LJF68_RS22190 (4555423) 4555423..4556700 + 1278 WP_000803764.1 branched chain amino acid ABC transporter permease LivM -
LJF68_RS22195 (4556697) 4556697..4557464 + 768 WP_000082080.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
LJF68_RS22200 (4557466) 4557466..4558179 + 714 WP_000416114.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
LJF68_RS22205 (4558310) 4558310..4558531 + 222 WP_001522145.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LJF68_RS22210 (4558528) 4558528..4558896 + 369 WP_000174964.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
LJF68_RS22215 (4559155) 4559155..4560471 + 1317 WP_000624755.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
LJF68_RS22220 (4560576) 4560576..4561463 + 888 WP_000099303.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
LJF68_RS22225 (4561460) 4561460..4562305 + 846 WP_000572196.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
LJF68_RS22230 (4562307) 4562307..4563377 + 1071 WP_000907840.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4555423..4564114 8691


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(6-114)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-49)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13601.91 Da        Isoelectric Point: 6.7252

>T221902 WP_000174964.1 NZ_CP085816:4558528-4558896 [Salmonella enterica subsp. enterica serovar Enteritidis]
MTLQLISAEEIIQFHDRLLRVTPGVTGMPDPGRAEALMYRVLNQIEYEGVTDVWLLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGISLAANPDFVDMTVDAAAGRLTLEQIVVRLRA

Download         Length: 369 bp

>T221902 NZ_CP117620:c3528713-3528561 [Escherichia albertii]
ATGCTAACAAAATATGCCCTTGTGGCAATCATAGTGCTGTGTTGTACAGTGCTGGGATTCACGCTGATGGTAGGCGACTC
GTTGTGTGAGTTGAGTATCAGAGAACGTGGTATGGAGTTTAAGGCAGTTCTCGCTTACGAATCGAAGAAGTAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8166.17 Da        Isoelectric Point: 5.0775

>AT221902 WP_001522145.1 NZ_CP085816:4558310-4558531 [Salmonella enterica subsp. enterica serovar Enteritidis]
MRTVNYSEARQNLAEVLESAVTAGPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGNELRELADK

Download         Length: 222 bp

>AT221902 NZ_CP117620:3528755-3528807 [Escherichia albertii]
TTAGGTTCGAACGCTGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V9X0E4

Antitoxin

Source ID Structure

References