Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3779887..3780416 Replicon chromosome
Accession NC_009525
Organism Mycobacterium tuberculosis H37Ra

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag MRA_RS17845 Protein ID WP_003417760.1
Coordinates 3780159..3780416 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag MRA_RS17840 Protein ID WP_003417757.1
Coordinates 3779887..3780162 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MRA_RS22845 3776685..3778122 - 1438 Protein_3485 FAD-binding oxidoreductase -
MRA_RS17825 3778225..3778614 + 390 WP_003417745.1 DUF732 domain-containing protein -
MRA_RS17830 3778628..3778921 - 294 WP_003417749.1 DUF3017 domain-containing protein -
MRA_RS17835 3778918..3779763 - 846 WP_003417751.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
MRA_RS17840 3779887..3780162 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
MRA_RS17845 3780159..3780416 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
MRA_RS17850 3780458..3781648 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
MRA_RS17855 3781765..3782133 + 369 WP_003417765.1 FHA domain-containing protein -
MRA_RS17860 3782130..3782681 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
MRA_RS17865 3782688..3783269 - 582 WP_003417769.1 ATP/GTP-binding protein -
MRA_RS17870 3783250..3783618 - 369 WP_003417772.1 DUF742 domain-containing protein -
MRA_RS17875 3783596..3783988 - 393 WP_003417776.1 roadblock/LC7 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T22190 WP_003417760.1 NC_009525:3780159-3780416 [Mycobacterium tuberculosis H37Ra]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

>T22190 NC_009525:3780159-3780416 [Mycobacterium tuberculosis H37Ra]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTGGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT22190 WP_003417757.1 NC_009525:3779887-3780162 [Mycobacterium tuberculosis H37Ra]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp

>AT22190 NC_009525:3779887-3780162 [Mycobacterium tuberculosis H37Ra]
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
PDB 3CTO
PDB 3OEI
PDB 3D55
AlphaFold DB G0TI94

References