Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3747471..3748252 Replicon chromosome
Accession NZ_CP085816
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Slowpoke

Toxin (Protein)


Gene name TacT2 Uniprot ID B5R980
Locus tag LJF68_RS18515 Protein ID WP_000626100.1
Coordinates 3747471..3747962 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag LJF68_RS18520 Protein ID WP_001110452.1
Coordinates 3747959..3748252 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF68_RS18480 (3742930) 3742930..3743277 + 348 WP_000887832.1 divalent cation tolerance protein CutA -
LJF68_RS18485 (3743253) 3743253..3744956 + 1704 WP_000068885.1 protein-disulfide reductase DsbD -
LJF68_RS18490 (3744993) 3744993..3745568 + 576 WP_001188509.1 transcriptional regulator -
LJF68_RS18500 (3745840) 3745840..3745914 - 75 Protein_3607 helix-turn-helix domain-containing protein -
LJF68_RS18505 (3746294) 3746294..3746371 + 78 Protein_3608 porin family protein -
LJF68_RS18510 (3746471) 3746471..3747223 + 753 WP_000842433.1 non-specific acid phosphatase -
LJF68_RS18515 (3747471) 3747471..3747962 - 492 WP_000626100.1 GNAT family N-acetyltransferase Toxin
LJF68_RS18520 (3747959) 3747959..3748252 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
LJF68_RS18525 (3748569) 3748569..3748790 + 222 WP_001576552.1 hypothetical protein -
LJF68_RS18530 (3749057) 3749057..3749932 + 876 WP_000921676.1 AraC family transcriptional regulator -
LJF68_RS18535 (3749929) 3749929..3750216 + 288 WP_001541332.1 transcriptional regulator RtsB -
LJF68_RS18540 (3750209) 3750209..3750517 - 309 WP_072095651.1 ABC transporter ATP-binding protein -
LJF68_RS18545 (3750516) 3750516..3750764 + 249 Protein_3616 Ig-like domain-containing protein -
LJF68_RS18550 (3750876) 3750876..3751007 + 132 Protein_3617 hypothetical protein -
LJF68_RS18555 (3751301) 3751301..3752207 - 907 Protein_3618 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17645.45 Da        Isoelectric Point: 7.7297

>T221898 WP_000626100.1 NZ_CP085816:c3747962-3747471 [Salmonella enterica subsp. enterica serovar Enteritidis]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T221898 NZ_CP117620:2077661-2077816 [Escherichia albertii]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT221898 WP_001110452.1 NZ_CP085816:c3748252-3747959 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT221898 NZ_CP117620:c2077649-2077591 [Escherichia albertii]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATTTGTGAGACATAGATTGGGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IQ80

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References