Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3640549..3641065 Replicon chromosome
Accession NZ_CP085816
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Slowpoke

Toxin (Protein)


Gene name relE Uniprot ID B5R9I9
Locus tag LJF68_RS17940 Protein ID WP_000220582.1
Coordinates 3640549..3640833 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag LJF68_RS17945 Protein ID WP_000212724.1
Coordinates 3640823..3641065 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF68_RS17925 (3635759) 3635759..3637412 + 1654 Protein_3496 alpha,alpha-phosphotrehalase -
LJF68_RS17930 (3637821) 3637821..3639959 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
LJF68_RS17935 (3640081) 3640081..3640545 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LJF68_RS17940 (3640549) 3640549..3640833 - 285 WP_000220582.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LJF68_RS17945 (3640823) 3640823..3641065 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LJF68_RS17950 (3641143) 3641143..3643058 - 1916 Protein_3501 BglG family transcription antiterminator -
LJF68_RS17955 (3643075) 3643075..3643815 - 741 WP_000779259.1 KDGP aldolase family protein -
LJF68_RS17960 (3643812) 3643812..3644930 - 1119 WP_001139169.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
LJF68_RS17965 (3644914) 3644914..3646047 - 1134 WP_000459957.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10912.66 Da        Isoelectric Point: 9.6743

>T221897 WP_000220582.1 NZ_CP085816:c3640833-3640549 [Salmonella enterica subsp. enterica serovar Enteritidis]
MTYELEFDPRALKEWHKLGDTVQAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T221897 NZ_CP117620:c2064795-2064601 [Escherichia albertii]
ATGCGATATGAAAAAGTTAAGCCATGTCCGTTTTGTGGTTGTCCATCTGTAACAGTGAAAGCCATTTCAGGGTGTTACCG
GGCAAAATGCAACGGCTGCGAATCCCGAACTGGCTATGGTGGAAGTGAGAAAGAAGCCCTCGAAAGATGGAATAAACGAA
CCGCTGAAAATATTAATGGAGGCATCTATGTATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT221897 WP_000212724.1 NZ_CP085816:c3641065-3640823 [Salmonella enterica subsp. enterica serovar Enteritidis]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT221897 NZ_CP117620:2064425-2064602 [Escherichia albertii]
AGGACTGAAGTTTCTCGCAATTAAAATTCATCAGTTTTACATTTTGCTCTCTGGAAACGCCTGCTTCTTTTTTCCCTGAG
AGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTACCTCCTTCCTTTTC
AATTGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656ILJ8

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References