Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 3599420..3599970 Replicon chromosome
Accession NZ_CP085816
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Slowpoke

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag LJF68_RS17720 Protein ID WP_001199743.1
Coordinates 3599420..3599728 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7RP97
Locus tag LJF68_RS17725 Protein ID WP_001118105.1
Coordinates 3599731..3599970 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF68_RS17700 (3595989) 3595989..3596600 - 612 WP_001706282.1 SEF14/SEF18 fimbria chaperone SefB -
LJF68_RS17705 (3596853) 3596853..3597383 - 531 WP_000909461.1 SEF14 fimbria major subunit SefA -
LJF68_RS17710 (3597709) 3597709..3598842 + 1134 Protein_3456 IS3 family transposase -
LJF68_RS17715 (3598874) 3598874..3599014 - 141 Protein_3457 Arm DNA-binding domain-containing protein -
LJF68_RS17720 (3599420) 3599420..3599728 - 309 WP_001199743.1 CcdB family protein Toxin
LJF68_RS17725 (3599731) 3599731..3599970 - 240 WP_001118105.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
LJF68_RS17730 (3600079) 3600079..3600327 - 249 WP_000168388.1 ribbon-helix-helix domain-containing protein -
LJF68_RS17735 (3600404) 3600404..3600949 - 546 WP_223151225.1 helix-turn-helix domain-containing protein -
LJF68_RS17750 (3601706) 3601706..3602725 + 1020 WP_000152558.1 NAD(P)-dependent alcohol dehydrogenase -
LJF68_RS17755 (3602753) 3602753..3603284 - 532 Protein_3463 gluconokinase -
LJF68_RS17760 (3603501) 3603501..3604532 + 1032 WP_000453347.1 L-idonate 5-dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 3597801..3600904 3103


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T221896 WP_001199743.1 NZ_CP085816:c3599728-3599420 [Salmonella enterica subsp. enterica serovar Enteritidis]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

>T221896 NZ_CP117620:1804383-1804538 [Escherichia albertii]
ATGAAGCAGCAAAAGGCGATGTTAGTCGCCCTGATCGTCATCTGTTTAACCGTCATTGTTACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGTCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8719.90 Da        Isoelectric Point: 6.4633

>AT221896 WP_001118105.1 NZ_CP085816:c3599970-3599731 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp

>AT221896 NZ_CP117620:c1804371-1804313 [Escherichia albertii]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTCTAGCATGAAATTGGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A5H9SZK8

References