Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2979595..2980215 Replicon chromosome
Accession NZ_CP085816
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Slowpoke

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag LJF68_RS14850 Protein ID WP_001280991.1
Coordinates 2979997..2980215 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag LJF68_RS14845 Protein ID WP_000344807.1
Coordinates 2979595..2979969 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF68_RS14835 (2974734) 2974734..2975927 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LJF68_RS14840 (2975950) 2975950..2979099 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
LJF68_RS14845 (2979595) 2979595..2979969 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
LJF68_RS14850 (2979997) 2979997..2980215 + 219 WP_001280991.1 HHA domain-containing protein Toxin
LJF68_RS14855 (2980394) 2980394..2980945 + 552 WP_001278793.1 maltose O-acetyltransferase -
LJF68_RS14860 (2981063) 2981063..2981533 + 471 WP_000136183.1 YlaC family protein -
LJF68_RS14865 (2981589) 2981589..2981729 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
LJF68_RS14870 (2981735) 2981735..2981995 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
LJF68_RS14875 (2982220) 2982220..2983770 + 1551 WP_000213140.1 EAL domain-containing protein -
LJF68_RS14885 (2984001) 2984001..2984390 + 390 WP_000961287.1 MGMT family protein -
LJF68_RS14890 (2984423) 2984423..2984992 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T221891 WP_001280991.1 NZ_CP085816:2979997-2980215 [Salmonella enterica subsp. enterica serovar Enteritidis]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T221891 NZ_CP117617:95069-95218 [Escherichia albertii]
ATGACGAAATATACCCTAATTGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT221891 WP_000344807.1 NZ_CP085816:2979595-2979969 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT221891 NZ_CP117617:c95025-94964 [Escherichia albertii]
TTAAGGTACTTCATGCAGGCCTCACGAGTTAATGGATTAACAAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References