Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3718483..3719157 Replicon chromosome
Accession NC_009525
Organism Mycobacterium tuberculosis H37Ra

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag MRA_RS17650 Protein ID WP_003417282.1
Coordinates 3718483..3718911 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag MRA_RS17655 Protein ID WP_003417286.1
Coordinates 3718915..3719157 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MRA_RS17625 3714305..3714706 - 402 WP_003417264.1 cytidine deaminase -
MRA_RS17630 3714847..3715281 + 435 WP_003900017.1 succinate dehydrogenase, cytochrome b556 subunit -
MRA_RS17635 3715278..3715712 + 435 WP_009936281.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
MRA_RS17640 3715841..3717613 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
MRA_RS17645 3717613..3718404 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
MRA_RS17650 3718483..3718911 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
MRA_RS17655 3718915..3719157 - 243 WP_003417286.1 ribbon-helix-helix domain-containing protein Antitoxin
MRA_RS17660 3719279..3719893 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
MRA_RS17665 3719890..3720555 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
MRA_RS17670 3720556..3721089 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
MRA_RS22835 3721086..3721238 - 153 WP_003916129.1 hypothetical protein -
MRA_RS17685 3721274..3722535 + 1262 WP_087902221.1 IS3-like element IS987 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T22189 WP_003417282.1 NC_009525:c3718911-3718483 [Mycobacterium tuberculosis H37Ra]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T22189 NC_009525:c3718911-3718483 [Mycobacterium tuberculosis H37Ra]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT22189 WP_003417286.1 NC_009525:c3719157-3718915 [Mycobacterium tuberculosis H37Ra]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT22189 NC_009525:c3719157-3718915 [Mycobacterium tuberculosis H37Ra]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References