Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4339422..4340082 Replicon chromosome
Accession NZ_CP085815
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Slowbro

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag LJF37_RS21155 Protein ID WP_000244756.1
Coordinates 4339669..4340082 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag LJF37_RS21150 Protein ID WP_000351186.1
Coordinates 4339422..4339688 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF37_RS21130 (4335351) 4335351..4336784 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
LJF37_RS21135 (4336942) 4336942..4337253 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
LJF37_RS21140 (4337417) 4337417..4338076 + 660 WP_000250289.1 hemolysin III family protein -
LJF37_RS21145 (4338192) 4338192..4339172 - 981 WP_000874176.1 tRNA-modifying protein YgfZ -
LJF37_RS21150 (4339422) 4339422..4339688 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
LJF37_RS21155 (4339669) 4339669..4340082 + 414 WP_000244756.1 protein YgfX Toxin
LJF37_RS21160 (4340135) 4340135..4340656 - 522 WP_001055885.1 flavodoxin FldB -
LJF37_RS21165 (4340769) 4340769..4341665 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
LJF37_RS21170 (4341689) 4341689..4342402 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LJF37_RS21175 (4342408) 4342408..4344141 + 1734 WP_000813389.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T221875 WP_000244756.1 NZ_CP085815:4339669-4340082 [Salmonella enterica subsp. enterica serovar Enteritidis]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T221875 NZ_CP117615:173282-173434 [Escherichia albertii]
ATGCCGCAGAAATATAGATTGCTTTCTTTAATAGTGATTTGTTTCACGCTTTTATTTTTCACCTGGATGATAAGGGATTC
ACTGTGTGAATTGCATATTAAACAGGGGAGTTATGAGCTGGCGGCGTTTTTAGCCTGCAATCTGAAAGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT221875 WP_000351186.1 NZ_CP085815:4339422-4339688 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT221875 NZ_CP117615:c173225-173177 [Escherichia albertii]
GCATAGAGGGGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References