Detailed information of TA system TA221873

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc-RelB
• Location: 3824705..3825291
• Replicon: chromosome
• Accession: NZ_CP085815
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain Slowbro

Toxin (Protein)

• Gene name: doc
• Uniprot ID: A0A3V9X0E4
• Locus tag: LJF37_RS18595
• Protein ID: WP_000174964.1
• Coordinates: 3824923..3825291 (+)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: V7IU48
• Locus tag: LJF37_RS18590
• Protein ID: WP_001522145.1
• Coordinates: 3824705..3824926 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJF37_RS18565 (3819726)	3819726..3820835	+	1110	WP_000822978.1	high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK	-
LJF37_RS18570 (3820895)	3820895..3821821	+	927	WP_000003007.1	high-affinity branched-chain amino acid ABC transporter permease LivH	-
LJF37_RS18575 (3821818)	3821818..3823095	+	1278	WP_000803764.1	branched chain amino acid ABC transporter permease LivM	-
LJF37_RS18580 (3823092)	3823092..3823859	+	768	WP_000082080.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG	-
LJF37_RS18585 (3823861)	3823861..3824574	+	714	WP_000416114.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF	-
LJF37_RS18590 (3824705)	3824705..3824926	+	222	WP_001522145.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
LJF37_RS18595 (3824923)	3824923..3825291	+	369	WP_000174964.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
LJF37_RS18600 (3825550)	3825550..3826866	+	1317	WP_000624755.1	sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB	-
LJF37_RS18605 (3826971)	3826971..3827858	+	888	WP_000099303.1	sn-glycerol-3-phosphate ABC transporter permease UgpA	-
LJF37_RS18610 (3827855)	3827855..3828700	+	846	WP_000572196.1	sn-glycerol-3-phosphate ABC transporter permease UgpE	-
LJF37_RS18615 (3828702)	3828702..3829772	+	1071	WP_000907840.1	sn-glycerol-3-phosphate import ATP-binding protein UgpC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3821818..3830509	8691

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Death on curing protein (6-114)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-49)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13601.91 Da
• Isoelectric Point: 6.7252

>T221873 WP_000174964.1 NZ_CP085815:3824923-3825291 [Salmonella enterica subsp. enterica serovar Enteritidis]
MTLQLISAEEIIQFHDRLLRVTPGVTGMPDPGRAEALMYRVLNQIEYEGVTDVWLLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGISLAANPDFVDMTVDAAAGRLTLEQIVVRLRA

Nucleotide

• Length: 369 bp

>T221873 NZ_CP117611:106506-106793 [Escherichia albertii]
ATGAGGTATCAGGTAAAATTCAGGGAAGATGCGCTGAAAGAGTGGCAAAAACTGGACAAGGCTATTCAGCAACAGTTTGC
GAAAAAGCTAAAAAAGTGCTGTGACAATCCGCATATTCCTTCCGCAAAACTGCGCGGGATAAAGGACTGCTACAAAATAA
AATTACGTGCGTCAGGTTTTCGCCTGGTCTATCAAGTGATTGACGAACAATTAATTATCGCTGTTGTAGCTGTGGGTAAA
CGTGAGCGCAGTGACGTTTATAATCTTGCCAGCGAAAGAATGAGATAA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8166.17 Da
• Isoelectric Point: 5.0775

>AT221873 WP_001522145.1 NZ_CP085815:3824705-3824926 [Salmonella enterica subsp. enterica serovar Enteritidis]
MRTVNYSEARQNLAEVLESAVTAGPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGNELRELADK

Nucleotide

• Length: 222 bp

>AT221873 NZ_CP117611:106258-106509 [Escherichia albertii]
ATGCCTAACATTATTCTCAGTGATACAAGCGCCAGTGTCAGCGAGCTGAAGAAAAACCCGATGGCGACAGTCAGCGCCGG
TGATGGTTTCCCGGTCGCTATCCTGAACCGTAATCAGCCTGCTTTCTACTGTGTACCCGCAGAGCTGTACGAAAAGATGC
TCGATGCCCTGGACGATCAGGAGCTGGTTAAACTGGTAGCCGAACGCAGCAACCAACCGCTGCATGATGTAGACCTGGAT
AAATACCTATGA

Structures

Toxin

• AlphaFold DB: A0A3V9X0E4