Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3714576..3715336 Replicon chromosome
Accession NZ_CP085815
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Slowbro

Toxin (Protein)


Gene name tacT Uniprot ID A0A1R2W0C7
Locus tag LJF37_RS18110 Protein ID WP_000533912.1
Coordinates 3714851..3715336 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag LJF37_RS18105 Protein ID WP_000965886.1
Coordinates 3714576..3714863 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF37_RS18085 (3709981) 3709981..3710892 + 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
LJF37_RS18090 (3710902) 3710902..3712971 + 2070 WP_001291741.1 glycine--tRNA ligase subunit beta -
LJF37_RS18095 (3713361) 3713361..3713759 + 399 Protein_3521 IS3 family transposase -
LJF37_RS18100 (3713931) 3713931..3714398 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
LJF37_RS18105 (3714576) 3714576..3714863 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
LJF37_RS18110 (3714851) 3714851..3715336 + 486 WP_000533912.1 GNAT family N-acetyltransferase Toxin
LJF37_RS18115 (3715707) 3715707..3716246 - 540 WP_000047147.1 copper-binding periplasmic metallochaperone CueP -
LJF37_RS18120 (3716420) 3716420..3716632 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
LJF37_RS18125 (3716920) 3716920..3717210 - 291 WP_000455790.1 HTH-type transcriptional regulator -
LJF37_RS18130 (3717649) 3717649..3718359 + 711 WP_000190524.1 DUF3053 domain-containing protein -
LJF37_RS18135 (3718409) 3718409..3719383 - 975 WP_000804678.1 glyoxylate/hydroxypyruvate reductase GhrB -
LJF37_RS18140 (3719602) 3719602..3720264 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17731.46 Da        Isoelectric Point: 9.8719

>T221872 WP_000533912.1 NZ_CP085815:3714851-3715336 [Salmonella enterica subsp. enterica serovar Enteritidis]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEVTGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T221872 NZ_CP117611:68853-69131 [Escherichia albertii]
ATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACCGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGATGGC
CGCCATTGAACTGGACGAACGGATTGGTTATTCCGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGCCGTG
TGGAAGGCACCCGGGAACTGGTTATTCACCCCCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTGTAT
ATCCTGCGCGTGTTGCATACCGCACAGAAGTGGCCATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT221872 WP_000965886.1 NZ_CP085815:3714576-3714863 [Salmonella enterica subsp. enterica serovar Enteritidis]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT221872 NZ_CP117611:68584-68853 [Escherichia albertii]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGTCAGACCGTTGAACGGCAGCATAATACCTGGTTCCATGACCAGGTTG
AGGCAGGACGTCAGCAACTCGAGCGCGGTGATATGCTTCCCCATGACATGGTCGAATCATCTGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAGGTCGCCGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1R2W0C7

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References