Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 2865841..2866391 Replicon chromosome
Accession NZ_CP085815
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Slowbro

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag LJF37_RS14105 Protein ID WP_001199743.1
Coordinates 2865841..2866149 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7RP97
Locus tag LJF37_RS14110 Protein ID WP_001118105.1
Coordinates 2866152..2866391 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF37_RS23105 (2861515) 2861515..2862396 - 882 WP_227792933.1 fimbria/pilus outer membrane usher protein -
LJF37_RS14085 (2862413) 2862413..2863090 - 678 WP_001691890.1 SEF14/SEF18 fimbria chaperone SefB -
LJF37_RS14090 (2863276) 2863276..2863806 - 531 WP_000909461.1 SEF14 fimbria major subunit SefA -
LJF37_RS14095 (2864130) 2864130..2865263 + 1134 Protein_2756 IS3 family transposase -
LJF37_RS14100 (2865295) 2865295..2865435 - 141 Protein_2757 Arm DNA-binding domain-containing protein -
LJF37_RS14105 (2865841) 2865841..2866149 - 309 WP_001199743.1 CcdB family protein Toxin
LJF37_RS14110 (2866152) 2866152..2866391 - 240 WP_001118105.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
LJF37_RS14115 (2866500) 2866500..2866748 - 249 WP_000168388.1 ribbon-helix-helix domain-containing protein -
LJF37_RS14120 (2866825) 2866825..2867370 - 546 WP_223151225.1 helix-turn-helix domain-containing protein -
LJF37_RS14135 (2868127) 2868127..2869146 + 1020 WP_000152558.1 NAD(P)-dependent alcohol dehydrogenase -
LJF37_RS14140 (2869174) 2869174..2869704 - 531 WP_000896758.1 gluconokinase -
LJF37_RS14145 (2869921) 2869921..2870952 + 1032 WP_000453347.1 L-idonate 5-dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 2864222..2867325 3103


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T221868 WP_001199743.1 NZ_CP085815:c2866149-2865841 [Salmonella enterica subsp. enterica serovar Enteritidis]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

>T221868 NZ_CP117609:3878048-3878389 [Escherichia albertii]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGCCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGCGATAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCCCCCGCCGCCGAAGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAAGCAGGTGCAGGAATTTATTGGGGTGATTGC
CGGTAAACAGAAAGTCGCGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8719.90 Da        Isoelectric Point: 6.4633

>AT221868 WP_001118105.1 NZ_CP085815:c2866391-2866152 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp

>AT221868 NZ_CP117609:c3878053-3877977 [Escherichia albertii]
AGTCATGATTACTATTCTCCATAAATAGTGATTGTGATGAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A5H9SZK8

References