Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 2821564..2822140 Replicon chromosome
Accession NZ_CP085815
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Slowbro

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag LJF37_RS13885 Protein ID WP_001131963.1
Coordinates 2821853..2822140 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag LJF37_RS13880 Protein ID WP_000063142.1
Coordinates 2821564..2821866 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF37_RS13865 (2818074) 2818074..2820224 + 2151 WP_000379928.1 pyruvate/proton symporter BtsT -
LJF37_RS13870 (2820319) 2820319..2820522 + 204 WP_000460616.1 YbdD/YjiX family protein -
LJF37_RS13875 (2820533) 2820533..2821489 + 957 WP_000187843.1 GTPase -
LJF37_RS13880 (2821564) 2821564..2821866 - 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
LJF37_RS13885 (2821853) 2821853..2822140 - 288 WP_001131963.1 BrnT family toxin Toxin
LJF37_RS13890 (2822557) 2822557..2823814 + 1258 Protein_2715 NERD domain-containing protein/DEAD/DEAH box helicase -
LJF37_RS13895 (2823808) 2823808..2823987 + 180 Protein_2716 DNA methyltransferase -
LJF37_RS13900 (2823977) 2823977..2825281 + 1305 WP_000863534.1 type I restriction-modification protein specificity subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T221867 WP_001131963.1 NZ_CP085815:c2822140-2821853 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

>T221867 NZ_CP117609:3802037-3802189 [Escherichia albertii]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT221867 WP_000063142.1 NZ_CP085815:c2821866-2821564 [Salmonella enterica subsp. enterica serovar Enteritidis]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp

>AT221867 NZ_CP117609:c3801988-3801931 [Escherichia albertii]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
PDB 7VD7
AlphaFold DB A0A4D6PB01

References