Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1738609..1739229 Replicon chromosome
Accession NZ_CP085814
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Plusle

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag LJF38_RS08175 Protein ID WP_001280991.1
Coordinates 1738609..1738827 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag LJF38_RS08180 Protein ID WP_000344807.1
Coordinates 1738855..1739229 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF38_RS08135 (1733832) 1733832..1734401 + 570 WP_000779802.1 YbaY family lipoprotein -
LJF38_RS08140 (1734434) 1734434..1734823 - 390 WP_000961287.1 MGMT family protein -
LJF38_RS08150 (1735054) 1735054..1736604 - 1551 WP_000213140.1 EAL domain-containing protein -
LJF38_RS08155 (1736829) 1736829..1737089 + 261 WP_000801415.1 type B 50S ribosomal protein L31 -
LJF38_RS08160 (1737095) 1737095..1737235 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
LJF38_RS08165 (1737291) 1737291..1737761 - 471 WP_000136183.1 YlaC family protein -
LJF38_RS08170 (1737879) 1737879..1738430 - 552 WP_001278793.1 maltose O-acetyltransferase -
LJF38_RS08175 (1738609) 1738609..1738827 - 219 WP_001280991.1 HHA domain-containing protein Toxin
LJF38_RS08180 (1738855) 1738855..1739229 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
LJF38_RS08185 (1739725) 1739725..1742874 - 3150 WP_001132508.1 efflux RND transporter permease AcrB -
LJF38_RS08190 (1742897) 1742897..1744090 - 1194 WP_227798739.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T221839 WP_001280991.1 NZ_CP085814:c1738827-1738609 [Salmonella enterica subsp. enterica serovar Enteritidis]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T221839 NZ_CP117606:c1281674-1281288 [Escherichia albertii]
ATGATTTGGGTCAGTGCACAGGAGGTCATTGCCTTCCACGATCGAATTTTGCAACGTTTTCCCGGTGTGGCGGGCCTGAC
TGACCCCGGCAGAGCACAGGCGTTGATTTATCGCGTGCAGAATCGTGTTCACTACGAGGGCGTTACTGACCTGTTTGAAC
TGGCAGCAACCTACTGGGTTGCCATCGCTCGCGGTCACATCTTTCATGATGGTAATAAACGTACCGCATTTTTCGTTACT
ATGACCTTTCTTTGGCGCAATGGCATCCGTATCCGTGACGTTGATAACTCGCTGGAGAACCTGACTGTCGAAGCGGCTAC
CGGAGAAAAAACGGTCGGTCAATTAGCACGATGTTTACGTGAACGAGTGGATAGTTCCGGGAATTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT221839 WP_000344807.1 NZ_CP085814:c1739229-1738855 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT221839 NZ_CP117606:c1281892-1281671 [Escherichia albertii]
ATGCAAACTTACACTTCCACACAAGCCAGAGCCAATATTGCCACTGTACTGGATACCGCGTTGAATGGTGAGCCAGTTGA
AATCACCCGTCGCGACGGCAGCTCTGCCGTGCTCATTAGTAAAGCCGCATTCGAGGCGTATCAAAATGCGAAACTGGACG
CGGAATTTGATGCCATCATGCAACGTCATGAACACACAATTGAAGCGTTGACTGATCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References