Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 970585..971366 Replicon chromosome
Accession NZ_CP085814
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Plusle

Toxin (Protein)


Gene name TacT2 Uniprot ID B5R980
Locus tag LJF38_RS04505 Protein ID WP_000626100.1
Coordinates 970875..971366 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag LJF38_RS04500 Protein ID WP_001110452.1
Coordinates 970585..970878 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF38_RS04465 (966632) 966632..967537 + 906 WP_001268200.1 YjiK family protein -
LJF38_RS04470 (967831) 967831..967962 - 132 Protein_859 hypothetical protein -
LJF38_RS04475 (968074) 968074..968322 - 249 Protein_860 Ig-like domain-containing protein -
LJF38_RS04480 (968321) 968321..968629 + 309 WP_072095651.1 ABC transporter ATP-binding protein -
LJF38_RS04485 (968622) 968622..968909 - 288 WP_001541332.1 transcriptional regulator RtsB -
LJF38_RS04490 (968906) 968906..969781 - 876 WP_000921676.1 AraC family transcriptional regulator -
LJF38_RS04495 (970047) 970047..970268 - 222 WP_001576552.1 hypothetical protein -
LJF38_RS04500 (970585) 970585..970878 + 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
LJF38_RS04505 (970875) 970875..971366 + 492 WP_000626100.1 GNAT family N-acetyltransferase Toxin
LJF38_RS04510 (971614) 971614..972366 - 753 WP_000842433.1 non-specific acid phosphatase -
LJF38_RS04515 (972466) 972466..972543 - 78 Protein_868 porin family protein -
LJF38_RS04520 (972923) 972923..972997 + 75 Protein_869 helix-turn-helix domain-containing protein -
LJF38_RS04530 (973268) 973268..973843 - 576 WP_001188509.1 transcriptional regulator -
LJF38_RS04535 (973880) 973880..975583 - 1704 WP_000068885.1 protein-disulfide reductase DsbD -
LJF38_RS04540 (975559) 975559..975906 - 348 WP_000887832.1 divalent cation tolerance protein CutA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17645.45 Da        Isoelectric Point: 7.7297

>T221832 WP_000626100.1 NZ_CP085814:970875-971366 [Salmonella enterica subsp. enterica serovar Enteritidis]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T221832 NZ_CP117601:123923-124210 [Escherichia albertii]
ATGAGGTATCAGGTAAAATTCAGGGAAGATGCGCTGAAAGAGTGGCAAAAACTGGACAAGGCTATTCAGCAACAGTTTGC
GAAAAAGCTAAAAAAGTGCTGTGACAATCCGCATATTCCTTCCGCAAAACTGCGCGGGATAAAGGACTGCTACAAAATAA
AATTACGTGCGTCAGGTTTTCGCCTGGTCTATCAAGTGATTGATGAACAATTAATTATCGCTGTTGTAGCTGTGGGTAAA
CGTAAGCGCAGTGACGTTTATAATCTTGCAAGTGAAAGAATGAGATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT221832 WP_001110452.1 NZ_CP085814:970585-970878 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT221832 NZ_CP117601:123675-123926 [Escherichia albertii]
ATGCCTAACATTATTCTCAGTGATACAAGCGCCAGTGTCAGCGAGCTGAAGAAAAACCCGATGGCGACAGTCAGTGCCGG
TGATGGTTTCCCGGTCGCTATCCTGAACCGTAATCAGCCTGCTTTCTACTGTGTACCCGCAGAGCTGTACGAAAAGATGC
TCGATGCCCTGGACGATCAGGAGCTGGTTAAACTGGTAGCCGAACGCAGCAACCAACCGCTGCATGATGTAGACCTGGAT
AAATACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IQ80

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References