Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 269948..270708 Replicon chromosome
Accession NZ_CP085814
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Plusle

Toxin (Protein)


Gene name tacT Uniprot ID A0A1R2W0C7
Locus tag LJF38_RS01295 Protein ID WP_000533912.1
Coordinates 269948..270433 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag LJF38_RS01300 Protein ID WP_000965886.1
Coordinates 270421..270708 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF38_RS01265 (265020) 265020..265682 + 663 WP_000747548.1 OmpA family lipoprotein -
LJF38_RS01270 (265901) 265901..266875 + 975 WP_000804678.1 glyoxylate/hydroxypyruvate reductase GhrB -
LJF38_RS01275 (266925) 266925..267635 - 711 WP_000190524.1 DUF3053 domain-containing protein -
LJF38_RS01280 (268074) 268074..268364 + 291 WP_000455790.1 HTH-type transcriptional regulator -
LJF38_RS01285 (268652) 268652..268864 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
LJF38_RS01290 (269038) 269038..269577 + 540 WP_000047147.1 copper-binding periplasmic metallochaperone CueP -
LJF38_RS01295 (269948) 269948..270433 - 486 WP_000533912.1 GNAT family N-acetyltransferase Toxin
LJF38_RS01300 (270421) 270421..270708 - 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
LJF38_RS01305 (270886) 270886..271353 - 468 WP_000702452.1 GNAT family N-acetyltransferase -
LJF38_RS01310 (271525) 271525..271923 - 399 Protein_255 IS3 family transposase -
LJF38_RS01315 (272313) 272313..274382 - 2070 WP_227798691.1 glycine--tRNA ligase subunit beta -
LJF38_RS01320 (274392) 274392..275303 - 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17731.46 Da        Isoelectric Point: 9.8719

>T221829 WP_000533912.1 NZ_CP085814:c270433-269948 [Salmonella enterica subsp. enterica serovar Enteritidis]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEVTGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T221829 NZ_CP117600:c4282453-4282235 [Escherichia albertii]
ATGTCCGATAAACCTTTAACAAAAACCGATTATTTGATGCGTCTGCGTCGCTGCCAGACAATTGACACGCTGGAACGTGT
TATCGAGAAAAATAAATATGAATTATCAGATAATGAATTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTTGCAGAGC
TGACTATGAATAAGCTATATGACAAGATCCCTTCCTCAGTGTGGAAATTCATTCGGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT221829 WP_000965886.1 NZ_CP085814:c270708-270421 [Salmonella enterica subsp. enterica serovar Enteritidis]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT221829 NZ_CP117600:c4282853-4282479 [Escherichia albertii]
ATGGATGAATACTCACCAAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGTAACCATGGCTGGGTAAATGACCCAACCTCGGCAATCAATCTACAGCTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAACAGATTGATGAATATCTG
GACGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAACCGATT
GTTCCGTTGCTTTGTTAACGCCACTAAAGCGAATCCTGCAAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1R2W0C7

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References