Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3747345..3748126 Replicon chromosome
Accession NZ_CP085813
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Minun

Toxin (Protein)


Gene name TacT2 Uniprot ID B5R980
Locus tag LJF39_RS18510 Protein ID WP_000626100.1
Coordinates 3747345..3747836 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag LJF39_RS18515 Protein ID WP_001110452.1
Coordinates 3747833..3748126 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF39_RS18475 (3742805) 3742805..3743152 + 348 WP_000887832.1 divalent cation tolerance protein CutA -
LJF39_RS18480 (3743128) 3743128..3744831 + 1704 WP_000068885.1 protein-disulfide reductase DsbD -
LJF39_RS18485 (3744868) 3744868..3745443 + 576 WP_001188509.1 transcriptional regulator -
LJF39_RS18495 (3745714) 3745714..3745788 - 75 Protein_3607 helix-turn-helix domain-containing protein -
LJF39_RS18500 (3746168) 3746168..3746245 + 78 Protein_3608 porin family protein -
LJF39_RS18505 (3746345) 3746345..3747097 + 753 WP_000842433.1 non-specific acid phosphatase -
LJF39_RS18510 (3747345) 3747345..3747836 - 492 WP_000626100.1 GNAT family N-acetyltransferase Toxin
LJF39_RS18515 (3747833) 3747833..3748126 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
LJF39_RS18520 (3748443) 3748443..3748664 + 222 WP_001576552.1 hypothetical protein -
LJF39_RS18525 (3748930) 3748930..3749805 + 876 WP_000921676.1 AraC family transcriptional regulator -
LJF39_RS18530 (3749802) 3749802..3750089 + 288 WP_001541332.1 transcriptional regulator RtsB -
LJF39_RS18535 (3750082) 3750082..3750390 - 309 WP_072095651.1 ABC transporter ATP-binding protein -
LJF39_RS18540 (3750389) 3750389..3750637 + 249 Protein_3616 Ig-like domain-containing protein -
LJF39_RS18545 (3750749) 3750749..3750880 + 132 Protein_3617 hypothetical protein -
LJF39_RS18550 (3751174) 3751174..3752079 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17645.45 Da        Isoelectric Point: 7.7297

>T221821 WP_000626100.1 NZ_CP085813:c3747836-3747345 [Salmonella enterica subsp. enterica serovar Enteritidis]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T221821 NZ_CP117600:c1068111-1067956 [Escherichia albertii]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGACCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT221821 WP_001110452.1 NZ_CP085813:c3748126-3747833 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT221821 NZ_CP117600:1068123-1068181 [Escherichia albertii]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTCTAGCATGAAATTGGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IQ80

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References