221820

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3640446..3640962 Replicon chromosome
Accession NZ_CP085813
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Minun

Toxin (Protein)


Gene name relE Uniprot ID B5R9I9
Locus tag LJF39_RS17935 Protein ID WP_000220582.1
Coordinates 3640446..3640730 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag LJF39_RS17940 Protein ID WP_000212724.1
Coordinates 3640720..3640962 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF39_RS17920 (3635656) 3635656..3637309 + 1654 Protein_3496 alpha,alpha-phosphotrehalase -
LJF39_RS17925 (3637718) 3637718..3639856 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
LJF39_RS17930 (3639978) 3639978..3640442 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LJF39_RS17935 (3640446) 3640446..3640730 - 285 WP_000220582.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LJF39_RS17940 (3640720) 3640720..3640962 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LJF39_RS17945 (3641040) 3641040..3642953 - 1914 WP_001212142.1 BglG family transcription antiterminator -
LJF39_RS17950 (3642970) 3642970..3643698 - 729 Protein_3502 KDGP aldolase family protein -
LJF39_RS17955 (3643708) 3643708..3644827 - 1120 Protein_3503 DgaE family pyridoxal phosphate-dependent ammonia lyase -
LJF39_RS17960 (3644811) 3644811..3645944 - 1134 WP_000459957.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10912.66 Da        Isoelectric Point: 9.6743

>T221820 WP_000220582.1 NZ_CP085813:c3640730-3640446 [Salmonella enterica subsp. enterica serovar Enteritidis]
MTYELEFDPRALKEWHKLGDTVQAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T221820 NZ_CP117600:c923083-922981 [Escherichia albertii]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAAAACA
GGAATCGTTTTCGGTCTCTTTTT

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT221820 WP_000212724.1 NZ_CP085813:c3640962-3640720 [Salmonella enterica subsp. enterica serovar Enteritidis]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT221820 NZ_CP117600:922979-923211 [Escherichia albertii]
ATAAAAAGAGACCGAAAACGATTCCTGTTTTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCGTACAAAATGGTCAG
TAAAAAGCGCGTCGGCCATCGTCTTAAATGTTAAAAACCGCCCGTTCTGGTGAAAGAACTGTGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656ILJ8

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References