Detailed information of TA system TA221815

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 2979483..2980103
• Replicon: chromosome
• Accession: NZ_CP085813
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain Minun

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: V1H8E6
• Locus tag: LJF39_RS14840
• Protein ID: WP_001280991.1
• Coordinates: 2979885..2980103 (+)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: -
• Locus tag: LJF39_RS14835
• Protein ID: WP_227790955.1
• Coordinates: 2979483..2979857 (+)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJF39_RS14825 (2974622)	2974622..2975815	+	1194	WP_001039202.1	multidrug efflux RND transporter periplasmic adaptor subunit AcrA	-
LJF39_RS14830 (2975838)	2975838..2978987	+	3150	WP_001132508.1	efflux RND transporter permease AcrB	-
LJF39_RS14835 (2979483)	2979483..2979857	+	375	WP_227790955.1	Hha toxicity modulator TomB	Antitoxin
LJF39_RS14840 (2979885)	2979885..2980103	+	219	WP_001280991.1	HHA domain-containing protein	Toxin
LJF39_RS14845 (2980282)	2980282..2980833	+	552	WP_001278793.1	maltose O-acetyltransferase	-
LJF39_RS14850 (2980951)	2980951..2981421	+	471	WP_000136183.1	YlaC family protein	-
LJF39_RS14855 (2981477)	2981477..2981617	-	141	WP_001197749.1	type B 50S ribosomal protein L36	-
LJF39_RS14860 (2981623)	2981623..2981883	-	261	WP_000801415.1	type B 50S ribosomal protein L31	-
LJF39_RS14865 (2982108)	2982108..2983658	+	1551	WP_000213140.1	EAL domain-containing protein	-
LJF39_RS14875 (2983889)	2983889..2984278	+	390	WP_000961287.1	MGMT family protein	-
LJF39_RS14880 (2984311)	2984311..2984880	-	570	WP_000779802.1	YbaY family lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-115)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8613.97 Da
• Isoelectric Point: 8.9008

>T221815 WP_001280991.1 NZ_CP085813:2979885-2980103 [Salmonella enterica subsp. enterica serovar Enteritidis]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Nucleotide

• Length: 219 bp

>T221815 NZ_CP117596:56903-57208 [Escherichia albertii]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTCCAGAGTGACATTATTGACAC
GCCTGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGTTGTCAGATAAGGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAGGAAGTG
GCTGATCTCAGCCACCGAGAAAATGACATCAAAAATGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 14354.13 Da
• Isoelectric Point: 4.8673

>AT221815 WP_227790955.1 NZ_CP085813:2979483-2979857 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATGANPVSLSC

Nucleotide

• Length: 375 bp

>AT221815 NZ_CP117596:56683-56901 [Escherichia albertii]
ATGAAGCAGCGCATTACAGTCACCGTCGACAGTGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGGCT
GGTAAGCACCACCCTGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGCAGGCAGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCCGACGAGAACAGGGACTGGTGA

Structures

Toxin

• PDB: 4ICG