Detailed information of TA system TA221802

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 359164..359824
• Replicon: chromosome
• Accession: NZ_CP085813
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain Minun

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: Q57K70
• Locus tag: LJF39_RS01770
• Protein ID: WP_000244756.1
• Coordinates: 359411..359824 (+)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: S5MU13
• Locus tag: LJF39_RS01765
• Protein ID: WP_000351186.1
• Coordinates: 359164..359430 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJF39_RS01745 (355093)	355093..356526	-	1434	WP_001230141.1	6-phospho-beta-glucosidase BglA	-
LJF39_RS01750 (356684)	356684..356995	+	312	WP_001182976.1	N(4)-acetylcytidine aminohydrolase	-
LJF39_RS01755 (357159)	357159..357818	+	660	WP_000250289.1	hemolysin III family protein	-
LJF39_RS01760 (357934)	357934..358914	-	981	WP_000874176.1	tRNA-modifying protein YgfZ	-
LJF39_RS01765 (359164)	359164..359430	+	267	WP_000351186.1	FAD assembly factor SdhE	Antitoxin
LJF39_RS01770 (359411)	359411..359824	+	414	WP_000244756.1	protein YgfX	Toxin
LJF39_RS01775 (359877)	359877..360398	-	522	WP_001055885.1	flavodoxin FldB	-
LJF39_RS01780 (360511)	360511..361407	+	897	WP_000434302.1	site-specific tyrosine recombinase XerD	-
LJF39_RS01785 (361431)	361431..362144	+	714	WP_000745614.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
LJF39_RS01790 (362150)	362150..363883	+	1734	WP_000813389.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 16183.15 Da
• Isoelectric Point: 10.7537

>T221802 WP_000244756.1 NZ_CP085813:359411-359824 [Salmonella enterica subsp. enterica serovar Enteritidis]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Nucleotide

• Length: 414 bp

>T221802 NZ_CP117595:c808107-807643 [Escherichia albertii]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAACCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTTTCGTCTCTTCTTTCGTTACAGCGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACACTGCGCACCTACGGTAAAAAAACAGATGCCTATACAGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCAAGAGACAGAAGAAAAGCATTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10550.05 Da
• Isoelectric Point: 6.0783

>AT221802 WP_000351186.1 NZ_CP085813:359164-359430 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT221802 NZ_CP117595:c808442-808107 [Escherichia albertii]
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCTGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCGACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Structures

Toxin

• AlphaFold DB: A0A3Z1E9V5

Antitoxin

• AlphaFold DB: A0A5I0YWH4