221793

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 3984931..3985453 Replicon chromosome
Accession NZ_CP085812
Organism Salmonella enterica subsp. enterica serovar Schwarzengrund strain Articuno

Toxin (Protein)


Gene name stbE Uniprot ID A0A5J1ICX1
Locus tag LJF40_RS19410 Protein ID WP_000221344.1
Coordinates 3984931..3985215 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag LJF40_RS19415 Protein ID WP_000885424.1
Coordinates 3985205..3985453 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF40_RS19385 (LJF40_19385) 3979935..3981176 - 1242 WP_001095723.1 MFS transporter -
LJF40_RS19390 (LJF40_19390) 3981166..3982674 - 1509 WP_000199421.1 FAD-dependent oxidoreductase -
LJF40_RS19395 (LJF40_19395) 3982719..3983207 + 489 WP_001293633.1 MarR family winged helix-turn-helix transcriptional regulator -
LJF40_RS19400 (LJF40_19400) 3983400..3984479 + 1080 WP_000954705.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
LJF40_RS19405 (LJF40_19405) 3984531..3984812 - 282 Protein_3771 RidA family protein -
LJF40_RS19410 (LJF40_19410) 3984931..3985215 - 285 WP_000221344.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LJF40_RS19415 (LJF40_19415) 3985205..3985453 - 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LJF40_RS19420 (LJF40_19420) 3985753..3986211 + 459 WP_000381836.1 hypothetical protein -
LJF40_RS19425 (LJF40_19425) 3986205..3986537 + 333 WP_000253166.1 DUF1493 family protein -
LJF40_RS19430 (LJF40_19430) 3986701..3987651 + 951 WP_000941990.1 toll/interleukin-1 receptor domain-containing protein -
LJF40_RS19435 (LJF40_19435) 3987722..3988297 - 576 Protein_3777 helix-turn-helix domain-containing protein -
LJF40_RS19440 (LJF40_19440) 3988712..3989635 - 924 WP_023230780.1 hypothetical protein -
LJF40_RS19445 (LJF40_19445) 3990069..3990284 - 216 WP_001530185.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3983400..3992584 9184


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11015.73 Da        Isoelectric Point: 10.5388

>T221793 WP_000221344.1 NZ_CP085812:c3985215-3984931 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKVTQHRS

Download         Length: 285 bp

>T221793 NZ_CP117590:3971085-3971237 [Escherichia albertii]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTATGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT221793 WP_000885424.1 NZ_CP085812:c3985453-3985205 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT221793 NZ_CP117590:c3971036-3970979 [Escherichia albertii]
GTTCTTCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5J1ICX1

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References