Detailed information of TA system TA221792

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 2925408..2926028
• Replicon: chromosome
• Accession: NZ_CP085812
• Organism: Salmonella enterica subsp. enterica serovar Schwarzengrund strain Articuno

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: V1H8E6
• Locus tag: LJF40_RS13910
• Protein ID: WP_001280991.1
• Coordinates: 2925408..2925626 (-)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: V1H4V6
• Locus tag: LJF40_RS13915
• Protein ID: WP_000344807.1
• Coordinates: 2925654..2926028 (-)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJF40_RS13870 (LJF40_13870)	2920631..2921200	+	570	WP_000779802.1	YbaY family lipoprotein	-
LJF40_RS13875 (LJF40_13875)	2921233..2921622	-	390	WP_000961285.1	MGMT family protein	-
LJF40_RS13885 (LJF40_13885)	2921853..2923403	-	1551	WP_000213134.1	EAL domain-containing protein	-
LJF40_RS13890 (LJF40_13890)	2923628..2923888	+	261	WP_000801415.1	type B 50S ribosomal protein L31	-
LJF40_RS13895 (LJF40_13895)	2923894..2924034	+	141	WP_001197749.1	type B 50S ribosomal protein L36	-
LJF40_RS13900 (LJF40_13900)	2924090..2924560	-	471	WP_000136183.1	YlaC family protein	-
LJF40_RS13905 (LJF40_13905)	2924678..2925229	-	552	WP_001278791.1	maltose O-acetyltransferase	-
LJF40_RS13910 (LJF40_13910)	2925408..2925626	-	219	WP_001280991.1	HHA domain-containing protein	Toxin
LJF40_RS13915 (LJF40_13915)	2925654..2926028	-	375	WP_000344807.1	Hha toxicity modulator TomB	Antitoxin
LJF40_RS13920 (LJF40_13920)	2926524..2929673	-	3150	WP_001132508.1	efflux RND transporter permease AcrB	-
LJF40_RS13925 (LJF40_13925)	2929696..2930889	-	1194	WP_001039202.1	multidrug efflux RND transporter periplasmic adaptor subunit AcrA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-116)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8613.97 Da
• Isoelectric Point: 8.9008

>T221792 WP_001280991.1 NZ_CP085812:c2925626-2925408 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Nucleotide

• Length: 219 bp

>T221792 NZ_CP117590:c3704555-3704214 [Escherichia albertii]
ATGTGGGACGTCGAGACAACGGAGACTTTCGACAACTGGTTTGATGCCCAGACTGTTGCGCTGAAAGAAGATTTACTTGC
TGCAATGCTGATTCTTGCAGAGTATGGCCCACAGTTGGGCAGACCCTTTGCGGACACGGTTAATGATTCACAGTTTTCAA
ATATGAAAGAATTACGCGTCCAACATCAGGGAAACCCGGTACGTGCTTTTTTTGCTTTCGATCCTGCGCGCCGTGGCATT
GTATTATGTGCAGGTGATAAAACGGGGTTAAATGAGAAAAAGTTTTATCGCGATATGATCAAGCTCGCTGATTCTGAATA
CCCTAAGCATCTGAAAAAGTAA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 14453.27 Da
• Isoelectric Point: 5.1444

>AT221792 WP_000344807.1 NZ_CP085812:c2926028-2925654 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Nucleotide

• Length: 375 bp

>AT221792 NZ_CP117590:c3704204-3703905 [Escherichia albertii]
ATGGCTACTCTAAAAGAACTGATAGCAAAGCAAAGCCCTGAAAGCCAGGCGCGTATTGCGGCAAAAGTTGAGGAAATGCG
CCAGACCATCGCCTTGCATCAGCTGAGAGAAGAACTCAATATTTCGCAAACGGAAATGGCGGCAGCGATGGGCATTAAGC
AACCGACCCTTGCAAAAATAGAGCAGGCAGATAACGATCCTCGGTTGTCTACGCTAAAACGCTATGTCGCGGCTTTAGGT
GGGGAATTGAGTATCGACGTTAAACTGCCTAATGGTAAGAGAGTTGCATTTCAGATTTAA

Structures

Toxin

• PDB: 4ICG

Antitoxin

• AlphaFold DB: A0A5I5FGI0