221791

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 2287945..2288495 Replicon chromosome
Accession NZ_CP085812
Organism Salmonella enterica subsp. enterica serovar Schwarzengrund strain Articuno

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag LJF40_RS10980 Protein ID WP_001199743.1
Coordinates 2288187..2288495 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A3V9PUN9
Locus tag LJF40_RS10975 Protein ID WP_000016243.1
Coordinates 2287945..2288184 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF40_RS10940 (LJF40_10940) 2283213..2283977 - 765 WP_000998688.1 gluconate 5-dehydrogenase -
LJF40_RS10945 (LJF40_10945) 2284002..2285033 - 1032 WP_000453358.1 L-idonate 5-dehydrogenase -
LJF40_RS10950 (LJF40_10950) 2285250..2285780 + 531 WP_000896756.1 gluconokinase -
LJF40_RS10955 (LJF40_10955) 2285808..2286827 - 1020 WP_000152563.1 NAD(P)-dependent alcohol dehydrogenase -
LJF40_RS10970 (LJF40_10970) 2287612..2287836 + 225 WP_031233173.1 ribbon-helix-helix protein, CopG family -
LJF40_RS10975 (LJF40_10975) 2287945..2288184 + 240 WP_000016243.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
LJF40_RS10980 (LJF40_10980) 2288187..2288495 + 309 WP_001199743.1 CcdB family protein Toxin
LJF40_RS10985 (LJF40_10985) 2288917..2289218 + 302 Protein_2126 Arm DNA-binding domain-containing protein -
LJF40_RS10990 (LJF40_10990) 2289580..2293095 + 3516 WP_000342548.1 AAA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T221791 WP_001199743.1 NZ_CP085812:2288187-2288495 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

>T221791 NZ_CP117590:c3693533-3693135 [Escherichia albertii]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGAAGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGCAGCGCATTTGGTATATTGTCAGGGCGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8679.83 Da        Isoelectric Point: 6.4633

>AT221791 WP_000016243.1 NZ_CP085812:2287945-2288184 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
MSGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRIADEHGLLSDDYRTF

Download         Length: 240 bp

>AT221791 NZ_CP117590:c3693829-3693536 [Escherichia albertii]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTTGAAGCATTAATGGACATGCTTG
CAGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCGAGTGCCGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V9PUN9

References