Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2247351..2247867 Replicon chromosome
Accession NZ_CP085812
Organism Salmonella enterica subsp. enterica serovar Schwarzengrund strain Articuno

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag LJF40_RS10765 Protein ID WP_000220578.1
Coordinates 2247583..2247867 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag LJF40_RS10760 Protein ID WP_000212724.1
Coordinates 2247351..2247593 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF40_RS10740 (LJF40_10740) 2242371..2243504 + 1134 WP_000459952.1 amidohydrolase/deacetylase family metallohydrolase -
LJF40_RS10745 (LJF40_10745) 2243488..2244606 + 1119 WP_001139165.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
LJF40_RS10750 (LJF40_10750) 2244603..2245343 + 741 WP_000779262.1 KDGP aldolase family protein -
LJF40_RS10755 (LJF40_10755) 2245360..2247273 + 1914 WP_001212145.1 BglG family transcription antiterminator -
LJF40_RS10760 (LJF40_10760) 2247351..2247593 + 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LJF40_RS10765 (LJF40_10765) 2247583..2247867 + 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LJF40_RS10770 (LJF40_10770) 2247871..2248335 - 465 WP_001009178.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LJF40_RS10775 (LJF40_10775) 2248552..2250690 - 2139 WP_000187827.1 anaerobic ribonucleoside-triphosphate reductase -
LJF40_RS10780 (LJF40_10780) 2251099..2252751 - 1653 WP_000155039.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T221790 WP_000220578.1 NZ_CP085812:2247583-2247867 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T221790 NZ_CP117590:3520889-3521107 [Escherichia albertii]
ATGTCCGATAAACCTTTAACAAAAACCGATTATTTGATGCGTCTGCGTCGCTGCCAGACAATTGACACGCTGGAACGTGT
TATCGAGAAAAATAAATATGAATTATCAGATAATGAATTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTTGCAGAGC
TGACTATGAATAAGCTATATGACAAGATCCCTTCCTCAGTGTGGAAATTCATTCGGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT221790 WP_000212724.1 NZ_CP085812:2247351-2247593 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT221790 NZ_CP117590:3520489-3520863 [Escherichia albertii]
ATGGATGAATACTCACCAAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGTAACCATGGCTGGGTAAATGACCCAACCTCGGCAATCAATCTACAGCTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAACAGATTGATGAATATCTG
GACGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAACCGATT
GTTCCGTTGCTTTGTTAACGCCACTAAAGCGAATCCTGCAAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References