Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2942038..2942752 Replicon chromosome
Accession NC_009525
Organism Mycobacterium tuberculosis H37Ra

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag MRA_RS13870 Protein ID WP_003413460.1
Coordinates 2942312..2942752 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag MRA_RS13865 Protein ID WP_003413456.1
Coordinates 2942038..2942325 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MRA_RS13830 2937460..2937705 + 246 WP_003413429.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
MRA_RS13835 2937702..2938106 + 405 WP_003899389.1 type II toxin-antitoxin system VapC family toxin -
MRA_RS13840 2938323..2938943 + 621 WP_003413441.1 DUF4178 domain-containing protein -
MRA_RS13845 2938954..2939448 + 495 WP_003413444.1 DUF2617 family protein -
MRA_RS13850 2939445..2939876 + 432 WP_003899390.1 DUF4247 domain-containing protein -
MRA_RS13855 2939931..2940359 + 429 WP_178121172.1 DUF350 domain-containing protein -
MRA_RS13860 2940356..2941927 + 1572 WP_003899392.1 polyamine aminopropyltransferase -
MRA_RS13865 2942038..2942325 + 288 WP_003413456.1 antitoxin VapB41 Antitoxin
MRA_RS13870 2942312..2942752 + 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
MRA_RS13875 2942773..2943528 - 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
MRA_RS13880 2943661..2944257 - 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
MRA_RS13885 2944265..2945110 - 846 WP_003413466.1 acyl-CoA thioesterase II -
MRA_RS13890 2945139..2946038 - 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
MRA_RS13895 2946166..2946840 + 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T22179 WP_003413460.1 NC_009525:2942312-2942752 [Mycobacterium tuberculosis H37Ra]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

>T22179 NC_009525:2942312-2942752 [Mycobacterium tuberculosis H37Ra]
ATGCTGCTCTGTGACACCAACATCTGGCTGGCGTTGGCGCTTTCCGGACACGTGCACCACAGGGCCTCGCGCGCATGGCT
AGACACCATCAACGCGCCCGGAGTCATCCACTTTTGCCGCGCAACCCAACAGTCGCTCCTTCGGCTGTTGACGAATCGGA
CGGTGCTGGGCGCGTATGGCAGCCCACCACTGACCAACCGCGAAGCGTGGGCGGCCTATGCCGCGTTCCTGGATGACGAC
CGCATCGTGCTGGCCGGCGCCGAACCTGATGGTTTGGAGGCCCAGTGGAGAGCCTTCGCCGTTCGCCAGTCGCCGGCGCC
CAAGGTTTGGATGGATGCCTACCTAGCTGCTTTCGCACTTACCGGTGGATTCGAGTTGGTGACGACTGACACCGCCTTCA
CCCAGTACGGCGGAATCGAGCTGCGGCTCCTGGCCAAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT22179 WP_003413456.1 NC_009525:2942038-2942325 [Mycobacterium tuberculosis H37Ra]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp

>AT22179 NC_009525:2942038-2942325 [Mycobacterium tuberculosis H37Ra]
ATGAAGACCACGCTCGACCTGCCTGATGAACTGATGCGCGCTATCAAGGTCCGCGCGGCGCAGCAGGGCCGCAAGATGAA
AGATGTCGTGACCGAACTGCTCAGATCCGGTCTGTCCCAGACGCACAGCGGGGCTCCAATCCCAACGCCGCGGCGCGTGC
AGCTTCCCCTGGTGCATTGCGGTGGCGCGGCTACCCGCGAACAAGAAATGACGCCGGAGCGTGTTGCCGCGGCCTTGCTC
GACCAGGAGGCCCAGTGGTGGTCCGGACACGACGATGCTGCTCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References