Detailed information of TA system TA022179

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 2942038..2942752
• Replicon: chromosome
• Accession: NC_009525
• Organism: Mycobacterium tuberculosis H37Ra

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0TQK0
• Locus tag: MRA_RS13870
• Protein ID: WP_003413460.1
• Coordinates: 2942312..2942752 (+)
• Length: 147 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: P9WJ20
• Locus tag: MRA_RS13865
• Protein ID: WP_003413456.1
• Coordinates: 2942038..2942325 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MRA_RS13830	2937460..2937705	+	246	WP_003413429.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
MRA_RS13835	2937702..2938106	+	405	WP_003899389.1	type II toxin-antitoxin system VapC family toxin	-
MRA_RS13840	2938323..2938943	+	621	WP_003413441.1	DUF4178 domain-containing protein	-
MRA_RS13845	2938954..2939448	+	495	WP_003413444.1	DUF2617 family protein	-
MRA_RS13850	2939445..2939876	+	432	WP_003899390.1	DUF4247 domain-containing protein	-
MRA_RS13855	2939931..2940359	+	429	WP_178121172.1	DUF350 domain-containing protein	-
MRA_RS13860	2940356..2941927	+	1572	WP_003899392.1	polyamine aminopropyltransferase	-
MRA_RS13865	2942038..2942325	+	288	WP_003413456.1	antitoxin VapB41	Antitoxin
MRA_RS13870	2942312..2942752	+	441	WP_003413460.1	type II toxin-antitoxin system VapC family toxin	Toxin
MRA_RS13875	2942773..2943528	-	756	WP_003413464.1	YebC/PmpR family DNA-binding transcriptional regulator	-
MRA_RS13880	2943661..2944257	-	597	WP_003413465.1	pyridoxal 5'-phosphate synthase glutaminase subunit PdxT	-
MRA_RS13885	2944265..2945110	-	846	WP_003413466.1	acyl-CoA thioesterase II	-
MRA_RS13890	2945139..2946038	-	900	WP_003413468.1	pyridoxal 5'-phosphate synthase lyase subunit PdxS	-
MRA_RS13895	2946166..2946840	+	675	WP_003413471.1	pyridoxamine 5'-phosphate oxidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (1-146)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 147 a.a.
• Molecular weight: 16026.38 Da
• Isoelectric Point: 6.8599

>T22179 WP_003413460.1 NC_009525:2942312-2942752 [Mycobacterium tuberculosis H37Ra]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Nucleotide

• Length: 441 bp

>T22179 NC_009525:2942312-2942752 [Mycobacterium tuberculosis H37Ra]
ATGCTGCTCTGTGACACCAACATCTGGCTGGCGTTGGCGCTTTCCGGACACGTGCACCACAGGGCCTCGCGCGCATGGCT
AGACACCATCAACGCGCCCGGAGTCATCCACTTTTGCCGCGCAACCCAACAGTCGCTCCTTCGGCTGTTGACGAATCGGA
CGGTGCTGGGCGCGTATGGCAGCCCACCACTGACCAACCGCGAAGCGTGGGCGGCCTATGCCGCGTTCCTGGATGACGAC
CGCATCGTGCTGGCCGGCGCCGAACCTGATGGTTTGGAGGCCCAGTGGAGAGCCTTCGCCGTTCGCCAGTCGCCGGCGCC
CAAGGTTTGGATGGATGCCTACCTAGCTGCTTTCGCACTTACCGGTGGATTCGAGTTGGTGACGACTGACACCGCCTTCA
CCCAGTACGGCGGAATCGAGCTGCGGCTCCTGGCCAAGTGA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10453.98 Da
• Isoelectric Point: 7.2797

>AT22179 WP_003413456.1 NC_009525:2942038-2942325 [Mycobacterium tuberculosis H37Ra]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Nucleotide

• Length: 288 bp

>AT22179 NC_009525:2942038-2942325 [Mycobacterium tuberculosis H37Ra]
ATGAAGACCACGCTCGACCTGCCTGATGAACTGATGCGCGCTATCAAGGTCCGCGCGGCGCAGCAGGGCCGCAAGATGAA
AGATGTCGTGACCGAACTGCTCAGATCCGGTCTGTCCCAGACGCACAGCGGGGCTCCAATCCCAACGCCGCGGCGCGTGC
AGCTTCCCCTGGTGCATTGCGGTGGCGCGGCTACCCGCGAACAAGAAATGACGCCGGAGCGTGTTGCCGCGGCCTTGCTC
GACCAGGAGGCCCAGTGGTGGTCCGGACACGACGATGCTGCTCTGTGA

Structures

Toxin

• AlphaFold DB: G0TQK0

Antitoxin

• AlphaFold DB: A0A7U4BWB8