Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2132454..2133235 Replicon chromosome
Accession NZ_CP085812
Organism Salmonella enterica subsp. enterica serovar Schwarzengrund strain Articuno

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A752VN12
Locus tag LJF40_RS10140 Protein ID WP_000622305.1
Coordinates 2132744..2133235 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A3V4SIN7
Locus tag LJF40_RS10135 Protein ID WP_001110453.1
Coordinates 2132454..2132747 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF40_RS10100 (LJF40_10100) 2128754..2129659 + 906 WP_001268205.1 YjiK family protein -
LJF40_RS10105 (LJF40_10105) 2129954..2130088 - 135 Protein_1956 hypothetical protein -
LJF40_RS10110 (LJF40_10110) 2130198..2130297 - 100 Protein_1957 hypothetical protein -
LJF40_RS10115 (LJF40_10115) 2130317..2130499 + 183 WP_001527266.1 ATP-binding cassette domain-containing protein -
LJF40_RS10120 (LJF40_10120) 2130492..2130779 - 288 WP_001269916.1 transcriptional regulator RtsB -
LJF40_RS10125 (LJF40_10125) 2130776..2131651 - 876 WP_000921676.1 AraC family transcriptional regulator -
LJF40_RS10130 (LJF40_10130) 2131915..2132137 - 223 Protein_1961 hypothetical protein -
LJF40_RS10135 (LJF40_10135) 2132454..2132747 + 294 WP_001110453.1 DUF1778 domain-containing protein Antitoxin
LJF40_RS10140 (LJF40_10140) 2132744..2133235 + 492 WP_000622305.1 GNAT family N-acetyltransferase Toxin
LJF40_RS10145 (LJF40_10145) 2133470..2133703 + 234 Protein_1964 IS481 family transposase -
LJF40_RS10150 (LJF40_10150) 2133978..2134205 - 228 WP_001112995.1 hypothetical protein -
LJF40_RS10155 (LJF40_10155) 2134794..2135078 + 285 WP_192917775.1 PapB/FocB family fimbrial expression transcriptional regulator -
LJF40_RS10160 (LJF40_10160) 2135113..2135652 + 540 WP_000721295.1 type 1 fimbrial protein -
LJF40_RS10165 (LJF40_10165) 2135662..2138100 + 2439 WP_001014136.1 F4 (K88) fimbrial usher FaeD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - faeC / faeD / faeE / faeF / faeH / faeI 2130492..2145741 15249


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(2-95)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17606.43 Da        Isoelectric Point: 7.7297

>T221789 WP_000622305.1 NZ_CP085812:2132744-2133235 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
MISAPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSSVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T221789 NZ_CP117590:c2810040-2809885 [Escherichia albertii]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGACCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10948.57 Da        Isoelectric Point: 9.8590

>AT221789 WP_001110453.1 NZ_CP085812:2132454-2132747 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT221789 NZ_CP117590:2810052-2810110 [Escherichia albertii]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTCTAGCATGAAATTGGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A752VN12

Antitoxin

Source ID Structure
AlphaFold DB A0A3V4SIN7

References