Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1364581..1365341 Replicon chromosome
Accession NZ_CP085812
Organism Salmonella enterica subsp. enterica serovar Schwarzengrund strain Articuno

Toxin (Protein)


Gene name tacT Uniprot ID A0A3V9PR68
Locus tag LJF40_RS06405 Protein ID WP_000533907.1
Coordinates 1364581..1365066 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag LJF40_RS06410 Protein ID WP_000965886.1
Coordinates 1365054..1365341 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF40_RS06375 (LJF40_06375) 1359643..1360305 + 663 WP_000747548.1 OmpA family lipoprotein -
LJF40_RS06380 (LJF40_06380) 1360535..1361509 + 975 WP_000804695.1 glyoxylate/hydroxypyruvate reductase GhrB -
LJF40_RS06385 (LJF40_06385) 1361559..1362269 - 711 WP_000190524.1 DUF3053 domain-containing protein -
LJF40_RS06390 (LJF40_06390) 1362708..1362998 + 291 WP_000455790.1 HTH-type transcriptional regulator -
LJF40_RS06395 (LJF40_06395) 1363286..1363498 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
LJF40_RS06400 (LJF40_06400) 1363671..1364210 + 540 WP_000047140.1 copper-binding periplasmic metallochaperone CueP -
LJF40_RS06405 (LJF40_06405) 1364581..1365066 - 486 WP_000533907.1 GNAT family N-acetyltransferase Toxin
LJF40_RS06410 (LJF40_06410) 1365054..1365341 - 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
LJF40_RS06415 (LJF40_06415) 1365519..1365986 - 468 WP_000702452.1 GNAT family N-acetyltransferase -
LJF40_RS06420 (LJF40_06420) 1366128..1366559 - 432 Protein_1247 IS3 family transposase -
LJF40_RS06425 (LJF40_06425) 1366821..1368890 - 2070 WP_001291738.1 glycine--tRNA ligase subunit beta -
LJF40_RS06430 (LJF40_06430) 1368900..1369811 - 912 WP_001168556.1 glycine--tRNA ligase subunit alpha -
LJF40_RS06435 (LJF40_06435) 1369950..1370252 - 303 WP_000605592.1 YsaB family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17715.46 Da        Isoelectric Point: 9.8719

>T221786 WP_000533907.1 NZ_CP085812:c1365066-1364581 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALIEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T221786 NZ_CP117590:2075690-2075792 [Escherichia albertii]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAAAACA
GGAATCGTTTTCGGTCTCTTTTT

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT221786 WP_000965886.1 NZ_CP085812:c1365341-1365054 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT221786 NZ_CP117590:c2075794-2075562 [Escherichia albertii]
ATAAAAAGAGACCGAAAACGATTCCTGTTTTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCGTACAAAATGGTCAG
TAAAAAGCGCGTCGGCCATCGTCTTAAATGTTAAAAACCGCCCGTTCTGGTGAAAGAACTGTGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V9PR68

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References