Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 757385..758045 Replicon chromosome
Accession NZ_CP085812
Organism Salmonella enterica subsp. enterica serovar Schwarzengrund strain Articuno

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag LJF40_RS03450 Protein ID WP_000244756.1
Coordinates 757385..757798 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag LJF40_RS03455 Protein ID WP_000351186.1
Coordinates 757779..758045 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF40_RS03430 (LJF40_03430) 753326..755059 - 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -
LJF40_RS03435 (LJF40_03435) 755065..755778 - 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LJF40_RS03440 (LJF40_03440) 755802..756698 - 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
LJF40_RS03445 (LJF40_03445) 756811..757332 + 522 WP_001055885.1 flavodoxin FldB -
LJF40_RS03450 (LJF40_03450) 757385..757798 - 414 WP_000244756.1 protein YgfX Toxin
LJF40_RS03455 (LJF40_03455) 757779..758045 - 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
LJF40_RS03460 (LJF40_03460) 758295..759275 + 981 WP_000874170.1 tRNA-modifying protein YgfZ -
LJF40_RS03465 (LJF40_03465) 759391..760050 - 660 WP_000250289.1 hemolysin III family protein -
LJF40_RS03470 (LJF40_03470) 760214..760525 - 312 WP_001182972.1 N(4)-acetylcytidine aminohydrolase -
LJF40_RS03475 (LJF40_03475) 760683..762116 + 1434 WP_001230152.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T221785 WP_000244756.1 NZ_CP085812:c757798-757385 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T221785 NZ_CP117590:1028661-1028813 [Escherichia albertii]
ATGCTGACAAAATATGCCCTTGTGGCAATCATCGTACTGTGTTGTACAGTACTGGGATTCACGCTGATGGTAGGCGACTC
GCTGTGTGAGTTGAGTATCAGAGAACGTGGTATGGAGTTTCAGGCAGTTCTCGCTTACGAATCGAAGAAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT221785 WP_000351186.1 NZ_CP085812:c758045-757779 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT221785 NZ_CP117590:c1028616-1028569 [Escherichia albertii]
GTTCGAACGTAGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References