Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4489368..4490128 Replicon chromosome
Accession NZ_CP085811
Organism Salmonella enterica subsp. enterica serovar Schwarzengrund strain Zapdos

Toxin (Protein)


Gene name tacT Uniprot ID A0A3V9PR68
Locus tag LJF41_RS22140 Protein ID WP_000533907.1
Coordinates 4489368..4489853 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag LJF41_RS22145 Protein ID WP_000965886.1
Coordinates 4489841..4490128 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF41_RS22110 (LJF41_22110) 4484431..4485093 + 663 WP_000747548.1 OmpA family lipoprotein -
LJF41_RS22115 (LJF41_22115) 4485322..4486296 + 975 WP_000804695.1 glyoxylate/hydroxypyruvate reductase GhrB -
LJF41_RS22120 (LJF41_22120) 4486346..4487056 - 711 WP_000190524.1 DUF3053 domain-containing protein -
LJF41_RS22125 (LJF41_22125) 4487495..4487785 + 291 WP_000455790.1 HTH-type transcriptional regulator -
LJF41_RS22130 (LJF41_22130) 4488073..4488285 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
LJF41_RS22135 (LJF41_22135) 4488458..4488997 + 540 WP_000047140.1 copper-binding periplasmic metallochaperone CueP -
LJF41_RS22140 (LJF41_22140) 4489368..4489853 - 486 WP_000533907.1 GNAT family N-acetyltransferase Toxin
LJF41_RS22145 (LJF41_22145) 4489841..4490128 - 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
LJF41_RS22150 (LJF41_22150) 4490306..4490773 - 468 WP_000702452.1 GNAT family N-acetyltransferase -
LJF41_RS22155 (LJF41_22155) 4490915..4491346 - 432 Protein_4308 IS3 family transposase -
LJF41_RS22160 (LJF41_22160) 4491608..4493677 - 2070 WP_001291738.1 glycine--tRNA ligase subunit beta -
LJF41_RS22165 (LJF41_22165) 4493687..4494598 - 912 WP_001168556.1 glycine--tRNA ligase subunit alpha -
LJF41_RS22170 (LJF41_22170) 4494737..4495039 - 303 WP_000605592.1 YsaB family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17715.46 Da        Isoelectric Point: 9.8719

>T221784 WP_000533907.1 NZ_CP085811:c4489853-4489368 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALIEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T221784 NZ_CP117590:879517-879921 [Escherichia albertii]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCGCAGTGGCTCTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGCTATTTTACTCATGCCCTGGCCGCTAAGTTATACCCCGTTATGGATGGTGTTGCTTTCGCTGGTGGTGTTTGATTGCG
TCCGCAGTCAGCGGCGCATTAATGCTCGTCAGGGGGAGATTCGCCTGTTGATGGATGGGCGTTTACGCTGGCAGGGGCAG
GAGTGGAGCATCGTCAGAGCGCCGTGGATGATTAAAACTGGCATGATGTTGCGTTTACTCTCTGATAGCGGCAAACGTCA
GCACCTGTGGCTGGCAGCCGACAGTATGGATGAAGCTGAATGGCGGGATTTGCGGCGAATTTTGTTACAACAAGAGATAC
AGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT221784 WP_000965886.1 NZ_CP085811:c4490128-4489841 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT221784 NZ_CP117590:879270-879536 [Escherichia albertii]
ATGGACATTAACAATAAAGCCCGCATTCACTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGATAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGACTGCTGGAATGTGACGATCCCGATT
TATTCAACTGGTTGATGAATCACGGTAAACCGGCCGACGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V9PR68

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References